Treatment of mitochondrial neurogastrointestinal encephalomyopathy with dialysis

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dc.contributor.authorYavuz, Haluk
dc.contributor.authorOzel, Ahmet
dc.contributor.authorChristensen, Mette
dc.contributor.authorChristensen, Ernst
dc.contributor.authorSchwartz, Marianne
dc.contributor.authorElmaci, Mithat
dc.contributor.authorVissing, John
dc.date.accessioned2020-03-26T17:18:42Z
dc.date.available2020-03-26T17:18:42Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To study the effect of continuous ambulatory peritoneal dialysis on nucleoside levels and clinical course in a patient with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Patient: We studied a patient with genetically verified MNGIE, who prior to treatment had lost weight progressively, developed amenorrhea, vomited multiple times daily, and had abdominal pain. Intervention: The patient was treated with peritoneal dialysis for 3 years, and the effect on symptoms and plasma concentrations of thymidine and deoxyuridine were monitored. Results: Dialysis stopped vomiting and reduced abdominal pain, and the patient gained 5 kg in weight and started to menstruate again. Symptoms returned if dialysis was paused. Dialysis did not affect plasma nucleoside levels. Conclusions: This study shows an unambiguous clinical benefit of peritoneal dialysis on gastrointestinal symptoms in MNGIE. Dialysis did not affect nucleoside levels, indicating elevated thymidine and deoxyuridine levels are not solely responsible for the pathogenesis of MNGIE.en_US
dc.identifier.doi10.1001/archneur.64.3.435en_US
dc.identifier.endpage438en_US
dc.identifier.issn0003-9942en_US
dc.identifier.issue3en_US
dc.identifier.pmid17353390en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://dx.doi.org/10.1001/archneur.64.3.435
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21719
dc.identifier.volume64en_US
dc.identifier.wosWOS:000244854600020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER MEDICAL ASSOCen_US
dc.relation.ispartofARCHIVES OF NEUROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleTreatment of mitochondrial neurogastrointestinal encephalomyopathy with dialysisen_US
dc.typeArticleen_US

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