Clinical and light microscopic studies of the conjunctival tissues of dogs with bilateral keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine

Basit Öğe Kaydı
dc.contributor.authorİzci, Celal
dc.contributor.authorÇelik, İlhami
dc.contributor.authorAlkan, Feyzanur
dc.contributor.authorErol, Muharrem
dc.contributor.authorSur, Emrah
dc.date.accessioned2020-03-26T19:01:22Z
dc.date.available2020-03-26T19:01:22Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe determined the concentrations of goblet and immune cells in conjunctival imprints and tissues of canines with keratoconjunctivitis sicca (KCS) before and after cyclosporine A (CsA) treatment. Twelve dogs with bilateral KCS were assigned to three groups: untreated, treatment group 1, and treatment group 2. The treatment groups were treated topically with 2% ophthalmic CsA solution for 45 days; CsA treatment group 2 was followed for an additional 30 days after discontinuation of the drug. Schirmer tear test (STT) scores were recorded prior to CsA treatment and on alternate days throughout the experiment. CsA treatment improved the STT scores, restored conjunctival histology, increased goblet and epithelial cell numbers, and decreased numbers of inflammatory cells. Although the STT scores regressed slightly at day 30 after discontinuing the treatment, the scores were higher than the baseline values. Topical CsA treatment resolved clinical signs of KCS, improved STT scores and restored normal conjunctival histology.en_US
dc.description.sponsorshipScientific Research Projects (BAP) Coordinating Office of Selcuk UniversitySelcuk University [110/2003]en_US
dc.description.sponsorshipScientific Research Projects (BAP) Coordinating Office of Selcuk University funded this study; Research Project Number 110/2003.en_US
dc.identifier.doi10.3109/10520295.2014.930177en_US
dc.identifier.endpage230en_US
dc.identifier.issn1052-0295en_US
dc.identifier.issn1473-7760en_US
dc.identifier.issue3en_US
dc.identifier.pmid25747049en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://dx.doi.org/10.3109/10520295.2014.930177
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31932
dc.identifier.volume90en_US
dc.identifier.wosWOS:000352110200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofBIOTECHNIC & HISTOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcanineen_US
dc.subjectconjunctivaen_US
dc.subjectcyclosporine Aen_US
dc.subjectkeratoconjunctivitis siccaen_US
dc.subjectmucosal immunityen_US
dc.titleClinical and light microscopic studies of the conjunctival tissues of dogs with bilateral keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu