The relationship between angiotensin-converting enzyme (insertion/deletion) gene polymorphism and left ventricular remodeling in acute myocardial infarction

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dc.contributor.authorÜlgen, Mehmet S.
dc.contributor.authorÖztürk, Önder
dc.contributor.authorAlan, Sait
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorTuran, Yaşar
dc.contributor.authorTekeş, Selahattin
dc.contributor.authorToprak, Nizamettin
dc.date.accessioned2020-03-26T17:19:32Z
dc.date.available2020-03-26T17:19:32Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: The development of left ventricular remodeling after acute myocardial infarction is a predictor of heart failure and mortality. The genetic influence on cardiac remodeling in the early period after acute myocardial infarction, is however, unclear. The aim ofthis study was to investigate the relationship between angiotensin-converting enzyme (ACE) gene polymorphism and left ventricular remodeling in the early period in patients with anterior myocardial infarction. METHOD: The study population consisted of 142 patients with their first attack of acute anterior myocardial infarction. Echocardiographic examinations were performed within 24 h of the first attack (first evaluation) and on the fifth day of acute myocardial infarction (second evaluation). Left ventricular end systolic and diastolic diameters, left ventricular end systolic and diastolic volumes, ejection fraction, mitral flow velocities (E, A, E/A), deceleration time, isovolumic relaxation time and myocardial performance index were calculated. ACE I/D polymorphism was determined using polymerase chain reaction amplification. RESULTS: On the basis of polymorphism of the ACE gene, the patients were classified into the three groups: group 1, deletion/deletion (n=59) genotype, group 2 insertion/deletion (n=69), and group 3 insertion/insertion (n=14) genotype. When the first and second sets of echocardiographic results of the groups were compared, all parameters were not different among three groups. In group analysis, Left ventricular systolic diameters, left ventricular diastolic diameters, left ventricular end diastolic diameters, left ventricular ejection fraction and myocardial performance index between first and second echocardiographic results were significantly different in deletion/deletion group and only myocardial performance index and left ventricular ejection fraction in insertion/deletion group (P<0.05). CONCLUSIONS: ACE gene polymorphism may influence early cardiac remodeling after acute myocardial infarction. Patients with the deletion/deletion-insertion/deletion genotype may be particularly more sensitive to ACE-I treatment possibly owing to the more prominent role of the renin-angiotensin system. © 2007 Lippincott Williams & Wilkins, Inc.en_US
dc.identifier.doi10.1097/MCA.0b013e328010a4c4en_US
dc.identifier.endpage157en_US
dc.identifier.issn0954-6928en_US
dc.identifier.issue3en_US
dc.identifier.pmid17429286en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MCA.0b013e328010a4c4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21891
dc.identifier.volume18en_US
dc.identifier.wosWOS:000246270900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAngiotensin-converting enzyme gene polymorphismen_US
dc.subjectMyocardial infarctionen_US
dc.subjectVentricular remodelingen_US
dc.titleThe relationship between angiotensin-converting enzyme (insertion/deletion) gene polymorphism and left ventricular remodeling in acute myocardial infarctionen_US
dc.typeArticleen_US

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