Non-dipping blood pressure patterns and arterial stiffness parameters in patients with Behcet's disease

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dc.contributor.authorCelik, Gulperi
dc.contributor.authorYilmaz, Sema
dc.contributor.authorEsmen, Serpil Ergulu
dc.date.accessioned2020-03-26T19:06:27Z
dc.date.available2020-03-26T19:06:27Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBehcet's disease is a multisystemic vasculitis involving veins and arteries of various sizes. Non-dipping status, augmentation index and pulse wave velocity are important determinants of cardiovascular mortality and morbidity. We investigated the non-dipping status and arterial stiffness in patients with Behcet's disease. In this cross-sectional study, we examined the vascular parameters of 96 patients with Behcet's disease (53% female) and 60 age- and sex-matched control subjects. The non-dipping status and arterial distensibility were assessed using a Mobil-O-Graph Arteriograph, an automatic oscillometric device. In total, 65.6% of 96 patients were systolic non-dippers, and 34.4% exhibited high augmentation indices. Ten percent of the control subjects were systolic non-dippers, and 11.7% exhibited high augmentation indices. Nocturnal decreases in systolic blood pressure correlated with central systolic blood pressure and diastolic blood pressure, as well as nocturnal decreases in diastolic blood pressure. Furthermore, non-dipper patients with Behcet's disease exhibited higher nocturnal cardiac outputs than did dipper patients with Behcet's disease. Augmentation index correlated negatively with C-reactive protein and correlated positively with both 24 h and nocturnal peripheral resistance, as well as 24 h pulse wave velocity. The patients with high augmentation indices exhibited lower creatinine clearance, as well as lower nocturnal cardiac outputs, higher 24 h peripheral resistance and higher 24 h pulse wave velocities. Non-dipping status and arterial stiffness may exacerbate the harmful cardiovascular effects of the other. In addition to conventional risk factors, non-dipping status and arterial stiffness should be examined during the follow-up evaluations of patients with Behcet's disease.en_US
dc.identifier.doi10.1038/hr.2015.86en_US
dc.identifier.endpage861en_US
dc.identifier.issn0916-9636en_US
dc.identifier.issn1348-4214en_US
dc.identifier.issue12en_US
dc.identifier.pmid26268564en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage856en_US
dc.identifier.urihttps://dx.doi.org/10.1038/hr.2015.86
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32365
dc.identifier.volume38en_US
dc.identifier.wosWOS:000367624600010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofHYPERTENSION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectaugmentation indexen_US
dc.subjectBehcet's diseaseen_US
dc.subjectcardiac outputen_US
dc.subjectnon-dipping statusen_US
dc.subjectpulse wave velocityen_US
dc.titleNon-dipping blood pressure patterns and arterial stiffness parameters in patients with Behcet's diseaseen_US
dc.typeArticleen_US

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