Novel capsules for potential theranostics of obscure gastrointestinal bleedings

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dc.contributor.authorColak, Bayram
dc.contributor.authorSakalak, Huseyin
dc.contributor.authorCavusoglu, Halit
dc.contributor.authorYavuz, Mustafa Selman
dc.date.accessioned2020-03-26T19:25:23Z
dc.date.available2020-03-26T19:25:23Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObscure gastrointestinal (GI) bleeding is identified as persistent or repeated bleeding from the gastrointestinal tract which could not be defined by conventional gastrointestinal endoscopy and radiological examinations. These GI bleedings are assessed through invasive diagnostic and treatment methods including enteroscopy, angiography and endoscopy. In addition, video capsule endoscopy (VCE) is a non-invasive method used to determine the location of the bleeding, however, this does not provide any treatment. Despite of these successful but invasive methods, an effective non-invasive treatment is desperately needed. Herein, we prepare non-invasive theranostic capsules to cure obscure GI bleeding. An effective theranostic capsule containing endothelin as the targeting agent, thrombin-fibrinogen or fibrin as the treating agent, and fluorescein dye as the diagnostic tool is suggested. These theranostic capsules can be administered orally in a simple and non-invasive manner without a risk of complication. By using these novel capsules, one can diagnose obscure GI bleeding with having a possibility of curing. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [214M232, 215S145]en_US
dc.description.sponsorshipThis work was supported by the grants from the Scientific and Technological Research Council of Turkey (TUBITAK Project No. 214M232 and 215S145).en_US
dc.identifier.doi10.1016/j.mehy.2016.07.006en_US
dc.identifier.endpage102en_US
dc.identifier.issn0306-9877en_US
dc.identifier.issn1532-2777en_US
dc.identifier.pmid27515212en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.mehy.2016.07.006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33837
dc.identifier.volume94en_US
dc.identifier.wosWOS:000382341300026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCHURCHILL LIVINGSTONEen_US
dc.relation.ispartofMEDICAL HYPOTHESESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleNovel capsules for potential theranostics of obscure gastrointestinal bleedingsen_US
dc.typeArticleen_US

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