The effects of estradiol on cardiac muscle electrophysiology in orchiectomized rat model: a new insight to side effects caused by castration

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dc.contributor.authorAyaz, M.
dc.contributor.authorAkand, M.
dc.contributor.authorKucukbagriacik, Y.
dc.contributor.authorDursunoglu, D.
dc.date.accessioned2020-03-26T19:07:28Z
dc.date.available2020-03-26T19:07:28Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJCTIVE: Although the testosterone has a protective effect on heart, patients having maximal androgen blockade due to prostate cancer resembles endothelial dysfunction and cardiac problems when compared to normal population. We aimed to test the effect of 17 beta estradiol on the orchiectomized male rat heart electrophysiology and ion channel expression levels. MATERIALS AND METHODS: This study was conducted on 27 male rats with 4 groups (healthy, orchiectomized, orchiectomized+ 17 beta estradiol treated and orchiectomized+ vehicle treated). Action potentials and contractions were recorded simultaneously, while expressions of the calcium and potassium ion channels were measured. RESULTS: Testosterone depletion for 4 weeks has caused a significant prolongation in the action potential durations and decrease in maximal contraction force as well as a deceleration. While this depletion suppressed expression of potassium channels, it increased the expression of calcium ion channels. Application of estradiol on the other hand, except for the calcium ion channel expression, had no positive effect on the tested parameters. CONCLUSIONS: Testosterone has a markedly important and protective effect on male cardiac muscle preparations while estrogen does not have any. It is predicted that testosterone has showed this effect by means of modulation of some key points of excitation-contraction pairing of cardiac muscle.en_US
dc.identifier.endpage2874en_US
dc.identifier.issn1128-3602en_US
dc.identifier.issue15en_US
dc.identifier.pmid26241542en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2866en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32643
dc.identifier.volume19en_US
dc.identifier.wosWOS:000359304500018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVERDUCI PUBLISHERen_US
dc.relation.ispartofEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectElectrophysiologyen_US
dc.subjectOrchiectomyen_US
dc.subjectRaten_US
dc.subject17 beta estradiolen_US
dc.subjectAndrogen depletionen_US
dc.titleThe effects of estradiol on cardiac muscle electrophysiology in orchiectomized rat model: a new insight to side effects caused by castrationen_US
dc.typeArticleen_US

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