Increased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgery

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dc.contributor.authorOncel, Muide
dc.contributor.authorKiyici, Aysel
dc.contributor.authorOncel, Murat
dc.contributor.authorSunam, Guven Sadi
dc.contributor.authorSahin, Emel
dc.contributor.authorAdam, Bahattin
dc.date.accessioned2020-03-26T19:24:42Z
dc.date.available2020-03-26T19:24:42Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: Videothoracoscopic surgery leads to general organ hypoperfusion by reducing mean arterial pressure, systemic vascular resistance, and end-diastolic volume index. Oxidative stress occurs as a result of hypoperfusion. Evaluation of the short-term effects of videothoracoscopic sympathectomy on serum ischemia-modified albumin (IMA), malondialdehyde (MDA), and nitric oxide (NO) levels in patients with primary hyperhidrosis was aimed. METHODS: Twenty-six patients who underwent videothoracoscopic surgery were contributed in this study. Venous blood samples were obtained from these patients 1 h before and after the surgery. IMA, MDA, and NO levels were measured in serum samples by colorimetric methods. Albumin concentrations were also measured for each sample, and albumin-adjusted IMA levels were calculated. RESULTS: Postoperative IMA, albumin-adjusted IMA, and MDA values were significantly higher compared to the preoperative values (P = 0.003, 0.027, 0.018, respectively). However, postoperative NO levels were lower than the preoperative values (P = 0.002). There was no significant difference between pre- and postoperative albumin concentrations, and there was no significant correlation between the parameters tested. CONCLUSIONS: We can conclude that elevation in MDA and IMA levels after videothoracoscopic surgery was caused by increased oxidative stress due to minimal ischemia-reperfusion injury after the infusion of CO 2 during the surgical process. Videothoracoscopic sympathectomy operation causes a decrease in NO production, and this should be taken in consideration when evaluating nitrosative stress in videothoracoscopic surgery.en_US
dc.identifier.doi10.4103/1817-1737.172298en_US
dc.identifier.endpage70en_US
dc.identifier.issn1817-1737en_US
dc.identifier.issn1998-3557en_US
dc.identifier.issue1en_US
dc.identifier.pmid26933460en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://dx.doi.org/10.4103/1817-1737.172298
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33708
dc.identifier.volume11en_US
dc.identifier.wosWOS:000369748200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONSen_US
dc.relation.ispartofANNALS OF THORACIC MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemia modified albuminen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectvideothoracoscopic surgeryen_US
dc.titleIncreased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgeryen_US
dc.typeArticleen_US

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