The Potential Effect of Epidural Anesthesia on Mesenteric Injury after Supraceliac Aortic Clamping in a Rabbit Model

Basit Öğe Kaydı
dc.contributor.authorOnoglu, Rasit
dc.contributor.authorNarin, Cuneyt
dc.contributor.authorKiyici, Aysel
dc.contributor.authorSarkilar, Gamze
dc.contributor.authorHacibeyoglu, Gurhan
dc.contributor.authorBaba, Fusun
dc.contributor.authorSarigul, Ali
dc.date.accessioned2020-03-26T19:31:43Z
dc.date.available2020-03-26T19:31:43Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Epidural anesthesia is known to increase blood flow by producing vasodilatation on mesenteric circulation. In this experimental study, we aim to examine the effect of epidural anesthesia on mesenteric ischemic-reperfusion ( IR) injury induced by supracoeliac aortic occlusion in a rabbit model. Methods: Twenty-eight male white New Zealand rabbits were assigned into 4 separate groups, with 7 rabbits in each group: group I, control group; group II, IR-only group; group III, IR plus epidural anesthesia group; group IV, epidural anesthesia-only group. IR model was produced by clamping supraceliac aorta with an atraumatic vascular clamp for 60 min, followed by reperfusion for 120 min. An epidural catheter was placed via Th12-L1 intervertebral space by using open technique before aortic clamping in those assigned to epidural anesthesia. IR injury was assessed using blood markers interleukin-6 and IMA and tissue markers superoxide dismutase and malondialdehyde. Also histopathological examination was performed to evaluate the degree of injury. Results: All biochemical markers in group II were significantly elevated in comparison with the other 3 groups ( p < 0.05). This was paralleled by a more severe histopathological injury in IR-only group ( group II). The group receiving IR plus epidural anesthesia ( group III) had lower biochemical marker levels as compared with the IR-only group ( group II). Conclusions: Mesenteric IR injury that can occur during abdominal aorta surgery can be reduced by epidural anesthesia, which is commonly used during or after major operations for pain control. Controlled clinical studies are required to evaluate these findings.en_US
dc.description.sponsorshipSelcuk University Scientific Projects Office [10102007]en_US
dc.description.sponsorshipThis study was financially supported by Selcuk University Scientific Projects Office (10102007).en_US
dc.identifier.doi10.1016/j.avsg.2015.11.013en_US
dc.identifier.endpage233en_US
dc.identifier.issn0890-5096en_US
dc.identifier.issn1615-5947en_US
dc.identifier.pmid26902941en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.avsg.2015.11.013
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34124
dc.identifier.volume34en_US
dc.identifier.wosWOS:000381685700024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofANNALS OF VASCULAR SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe Potential Effect of Epidural Anesthesia on Mesenteric Injury after Supraceliac Aortic Clamping in a Rabbit Modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu