A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood

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dc.contributor.authorOzarda, Yesim
dc.contributor.authorIchihara, Kiyoshi
dc.contributor.authorBakan, Ebubekir
dc.contributor.authorPolat, Harun
dc.contributor.authorOzturk, Nurinnisa
dc.contributor.authorBaygutalp, Nurcan K.
dc.contributor.authorTaneli, Fatma
dc.date.accessioned2020-03-26T19:33:29Z
dc.date.available2020-03-26T19:33:29Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: A nationwide multicentre study was conducted to establish well-defined reference intervals (Rls) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). Materials and methods: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method. The blood samples were analysed within 2 hours in each laboratory using Cell Dyn and Ruby (Abbott), LH780 (Beckman Coulter), or XT-2000i (Sysmex). A panel of freshly prepared blood from 40 healthy volunteers was measured in common to assess any analyser-dependent bias in the measurements. The SD ratio (SDR) based on ANOVA was used to judge the need for partitioning RVs. Rls were computed by the parametric method with/without applying the LAVE method. Results: Analyser-dependent bias was found for basophils (Bas), MCHC, RDW and MPV from the panel test results and thus those Rls were derived for each manufacturer. Rls were determined from all volunteers' results for WBC, neutrophils, lymphocytes, monocytes, eosinophils, MCV, MCH and platelets. Gender-specific Rls were required for RBC, haemoglobin, haematocrit, iron, UIBC and ferritin. Region-specific Rls were required for RBC, haemoglobin, haematocrit, UIBC, and TIBC. Conclusions: With the novel use of a freshly prepared blood panel, manufacturer-specific Rls' were derived for Bas, Bas%, MCHC, RDW and MPV. Regional differences in Rls were observed among the 7 regions of Turkey, which may be attributed to nutritional or environmental factors, including altitude.en_US
dc.description.sponsorshipResearch Fund of Uludag Universty [UAP(T)-2011/48]; Abbott Diagnostics (Abbott Laboratories, IL, USA); Becton Dickinson (BD Diagnostics, Oxford, England)en_US
dc.description.sponsorshipThis study was supported by the Research Fund of Uludag Universty (UAP(T)-2011/48), Abbott Diagnostics (Abbott Laboratories, IL, USA) and Becton Dickinson (BD Diagnostics, Oxford, England). We wish to thank Dr. David Armbruster from Abbott Diagnostics (Abbott Laboratories, IL, USA) for his kind support for realization of the study. We especially thank all the volunteers for their participation in this study. Finally, we are grateful to Professor Andrew Myron Johnson for his detailed scientific editing of this manuscript.en_US
dc.identifier.doi10.11613/BM.2017.038en_US
dc.identifier.endpage377en_US
dc.identifier.issn1330-0962en_US
dc.identifier.issn1846-7482en_US
dc.identifier.issue2en_US
dc.identifier.pmid28694726en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage350en_US
dc.identifier.urihttps://dx.doi.org/10.11613/BM.2017.038
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34727
dc.identifier.volume27en_US
dc.identifier.wosWOS:000404505700013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCROATIAN SOC MEDICAL BIOCHEMISTSen_US
dc.relation.ispartofBIOCHEMIA MEDICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmulticentre studyen_US
dc.subjectreference intervalsen_US
dc.subjectcomplete blood counten_US
dc.subjecthaematologyen_US
dc.subjectTurkeyen_US
dc.titleA nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blooden_US
dc.typeArticleen_US

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