Prognostic significance of flow cytometry findings in Turkish adult acute leukemia patients

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dc.contributor.authorBaştürk, A.
dc.contributor.authorAkıncı, S.
dc.contributor.authorHacıbekiroğlu, T.
dc.contributor.authorGüney, T.
dc.contributor.authorKutlucan, A.
dc.contributor.authorCeran, F.
dc.contributor.authorAkalın, S. D.
dc.date.accessioned2020-03-26T19:06:47Z
dc.date.available2020-03-26T19:06:47Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: Several factors are known to affect prognosis of acute leukemia such as age, high leukocyte count, cytogenetic abnormality, performance status and recurrent leukemia. We aimed to investigate the association between cell surface markers and prognostic determinants such as recurrence at 6 and 12 months and survival at 6, 12 and 18 months in acute leukemia patients. PATIENTS AND METHODS: A total of 142 patients, 101 with acute myeloid leukemia (AML) and 41 with B-cell acute lymphoblastic leukemia (B-ALL) were included. The effects of surface markers on survival and recurrence rates were evaluated retrospectively. RESULTS: In AML patients, CD5+ and CD34+ immunophenotypes and in ALL patients cCD22+, CD34+ and CD49f + CD19+ immunophenotypes were positive prognostic indicators. In AML patients CD7 expression, and in ALL patients CD5+, CD7+ and CD117+ immunophenotypes and >90% CD45 expression were negative prognostic indicators. CONCLUSIONS: This study demonstrates that flow cytometry, a common diagnostic tool in acute leukemia, may also have prognostic value in acute leukemia in the future.en_US
dc.identifier.endpage3366en_US
dc.identifier.issn1128-3602en_US
dc.identifier.issue18en_US
dc.identifier.pmid26439029en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3360en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32470
dc.identifier.volume19en_US
dc.identifier.wosWOS:000362577000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVERDUCI PUBLISHERen_US
dc.relation.ispartofEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute leukemiaen_US
dc.subjectFlow cytometryen_US
dc.subjectImmunophenotypeen_US
dc.subjectTurkishen_US
dc.titlePrognostic significance of flow cytometry findings in Turkish adult acute leukemia patientsen_US
dc.typeArticleen_US

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