The effects of melatonin and colchicine on ischemia-reperfusion injury in experimental rat testicular torsion model

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dc.contributor.authorSekmenli, Tamer
dc.contributor.authorGündüz, Metin
dc.contributor.authorÖztürk, Bahadır
dc.contributor.authorKarabağlı, Pınar
dc.contributor.authorÇiftçi, İlhan
dc.contributor.authorTekin, Gülsüm
dc.contributor.authorYılmaz, Mustafa
dc.date.accessioned2020-03-26T19:42:58Z
dc.date.available2020-03-26T19:42:58Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: The aim of the present study is to investigate the efficiency of colchicine and melatonin in an experimental rat testicular torsion model in the light of histological and biochemical data. Methods: A total of 34 Wistar albino male rats were randomly divided into 5 groups as: Group C (control, n= 6), Group S (sham; underwent only left scrotal exploration, n= 7), Group TD (torsion and detorsion; 6 h of ischemia and 7 days of reperfusion, n= 7), Group TD/M (TD + Melatonin; 6 h of ischemia and 7 days of reperfusion and 7 days of 17 mg/kg intraperitoneal melatonin per day, n = 7), group TD/Col (TD + Colchicine; 6 h of ischemia and 7 days of reperfusion and 7 days of 1 mg/kg oral colchicine per day, n = 7). Histopathologic evaluation of seminiferous tubule deterioration was performed by Johnsen's scoring system. Total antioxidant status (TAS), total oxidant status (TOS), IL-6, TNF alpha levels were analyzed in each group. Results: The histopathologic scores, total antioxidant status (TAS), total oxidant status (TOS), IL-6, TNF alpha levels in groups C and TD/Col were significantly lower than groups TD and TD/M (P < .001). Conclusion: Our study results revealed that colchicine reduced testicular ischemia-reperfusion injury in experimental rat testis torsion model. Although detorsion of testis is crucial for the preserving the testicular viability, antioxidant and anti-inflammatory treatment modalities like colchicine might help to reduce ischemia-reperfusion injury in detorsed testis. (C) 2017 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpedsurg.2016.11.035en_US
dc.identifier.endpage586en_US
dc.identifier.issn0022-3468en_US
dc.identifier.issn1531-5037en_US
dc.identifier.issue4en_US
dc.identifier.pmid27899171en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage582en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpedsurg.2016.11.035
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35568
dc.identifier.volume52en_US
dc.identifier.wosWOS:000400423700015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectColchicineen_US
dc.subjectMelatoninen_US
dc.subjectReperfusion injuryen_US
dc.subjectSpermatic cord torsionen_US
dc.subjectAntioxidantsen_US
dc.subjectRat testisen_US
dc.titleThe effects of melatonin and colchicine on ischemia-reperfusion injury in experimental rat testicular torsion modelen_US
dc.typeArticleen_US

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