Chronic (3-Weeks) Treatment of Estrogen (17 beta-Estradiol) Enhances Working and Reference Memory in Ovariectomized Rats: Role of Acetylcholine

Basit Öğe Kaydı
dc.contributor.authorUzum, Gulay
dc.contributor.authorBahcekapili, Nesrin
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorZiylan, Yusuf Ziya
dc.date.accessioned2020-03-26T19:23:19Z
dc.date.available2020-03-26T19:23:19Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractRecently there has been a growing interest in the effects of estrogen on cognitive functions. In this study, we aimed to examine 17 beta-estradiol treatment on working and reference memory in ovariectomized rats. We also examined the changes in the acetylcholine (ACh) levels in the brain areas associated with learning and memory. The study was performed on Sprague-Dawley type 3-month-old female rats. The rats were divided into four groups as control, ovariectomy (OVX), and OVX and estrogen treatment (10 A mu g/day i.p. 17 beta-estradiol) groups for 3 (OVX + E3) and 21 days OVX + E21). The rats were trained on eight arm radial maze task with eight arms baited to assess spatial memory, in addition four arms baited to assess both working and reference memory performances. The electron microscope images of the ACh vesicles in the frontal cortex, temporal cortex and hippocampus areas of the brain which are important regions for learning and memory were screened. Results showed that long term 17 beta-estradiol treatment has positive effects on both reference memory and working memory and that ACh vesicles increased in the examined brain areas, especially in hippocampus. Our results suggest that 3 weeks 17 beta-estradiol treatment may have an ameliorative effect on the memory through the central cholinergic system.en_US
dc.identifier.doi10.1007/s11064-016-1858-4en_US
dc.identifier.endpage1474en_US
dc.identifier.issn0364-3190en_US
dc.identifier.issn1573-6903en_US
dc.identifier.issue6en_US
dc.identifier.pmid26879199en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1468en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11064-016-1858-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33351
dc.identifier.volume41en_US
dc.identifier.wosWOS:000376076300028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER/PLENUM PUBLISHERSen_US
dc.relation.ispartofNEUROCHEMICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOvariectomyen_US
dc.subject17 beta-estradiol treatmenten_US
dc.subjectLearningen_US
dc.subjectAcetylcholineen_US
dc.subjectRaten_US
dc.titleChronic (3-Weeks) Treatment of Estrogen (17 beta-Estradiol) Enhances Working and Reference Memory in Ovariectomized Rats: Role of Acetylcholineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu