Effects of Coenzyme Q10 Supplementation on Exercise Performance and Markers of Oxidative Stress in Hemodialysis Patients: A Double-Blind Placebo-Controlled Crossover Trial

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dc.contributor.authorGokbel, Hakki
dc.contributor.authorTurk, Suleyman
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorAtalay, Huseyin
dc.contributor.authorBelviranli, Muaz
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorSolak, Yalcin
dc.date.accessioned2020-03-26T19:23:47Z
dc.date.available2020-03-26T19:23:47Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCoenzyme Q10 (CoQ10) supplementation has been shown to decrease oxidative stress in a number of clinical settings. However, there are mixed results regarding the role of CoQ10 supplementation on exercise performance. Chronic kidney disease is recognized as an inflammatory state, and hemodialysis patients have low level of exercise performance. We aimed to evaluate the effect of CoQ10 supplementation on oxidative stress markers and exercise performance measures. This was a prospective, double-blind, placebo-controlled, crossover study in which all patients received placebo and oral CoQ10 200 mg/d. Participants underwent 6-minute walking test and cycle ergometer. Blood samples were drawn to determine malondialdehyde, oxidized low-density lipoprotein, superoxide dismutase, and glutathione peroxidase. Walking distance in 6-minute walking test and estimated maximal oxygen consumption (VO2max) were recorded. Twenty-eight patients were randomized, but 23 patients completed the study protocol. Serum CoQ10 level significantly increased with supplementation compared with basal values (P < 0.05). Neither walking distance nor estimated VO2max was different between the placebo and CoQ10 groups (P > 0.05). Serum malondialdehyde levels significantly increased in both groups compared with baseline values just after the exercise (P < 0.05). There was no difference in markers of oxidative stress and antioxidant system between placebo and CoQ10 supplementation with exercise (P > 0.05). The results of this study showed no significant effect of CoQ10 supplementation on exercise performance measures and oxidative system markers compared with placebo in maintenance hemodialysis patients.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109S247]; Selcuk University Scientific Research Projects Coordinating OfficeSelcuk University [09102011]; ERA-EDTA fellowship programen_US
dc.description.sponsorshipThis project has been supported by TUBITAK (Project No.: 109S247) and Selcuk University Scientific Research Projects Coordinating Office (Project No.: 09102011). Dr. A. Gaipov received grant support from the ERA-EDTA fellowship program.en_US
dc.identifier.doi10.1097/MJT.0000000000000166en_US
dc.identifier.endpageE1743en_US
dc.identifier.issn1075-2765en_US
dc.identifier.issn1536-3686en_US
dc.identifier.issue6en_US
dc.identifier.pmid26844861en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE1736en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MJT.0000000000000166
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33495
dc.identifier.volume23en_US
dc.identifier.wosWOS:000388699800064en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofAMERICAN JOURNAL OF THERAPEUTICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoenzyme Q10en_US
dc.subjectexerciseen_US
dc.subjecthemodialysisen_US
dc.subjectoxidative stressen_US
dc.titleEffects of Coenzyme Q10 Supplementation on Exercise Performance and Markers of Oxidative Stress in Hemodialysis Patients: A Double-Blind Placebo-Controlled Crossover Trialen_US
dc.typeArticleen_US

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