Pharmacokinetics of marbofloxacin following intramuscular administration at different doses in sheep

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dc.contributor.authorAltan, Feray
dc.contributor.authorÇorum, Orhan
dc.contributor.authorÇorum, Duygu Durna
dc.contributor.authorAltan, Semih
dc.contributor.authorÜney, Kamil
dc.date.accessioned2020-03-26T20:19:07Z
dc.date.available2020-03-26T20:19:07Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThe pharmacokinetics of marbofloxacin (MBX) was determined following the intramuscular administration at the doses of 2, 4, 6, and 10 mg/kg in twenty-four healthy sheep. In parallel design, sheep were randomized to 2, 4, 6, and 10 mg/kg dose groups of six animals per group. High performance liquid chromatography method for determination of MBX in sheep plasma was used. Pharmacokinetic parameters were calculated by a non-compartmental method. The dose-normalized the area under the concentration-versus-time curve (AUC(0-infinity)) and dose-normalized maximum plasma concentration (C-max) in 10 mg/kg dose group were significantly higher than other dose groups. The elimination half-life (t(1/2 lambda z)) of marbofloxacin in 10 mg/kg dose group was significantly longer than other dose groups. MBX exhibited dose-proportional pharmacokinetics and was well tolerated after 2, 4, 6 and 10 mg/kg doses in sheep. The 2, 4, 6, and 10 mg/kg doses of MBX could be administered in the treatment of infections caused by susceptible pathogens in sheep. However, additional studies are needed to identify whether MBX is efficient in sheep of naturally infected with susceptible bacteria.en_US
dc.description.sponsorshipScientific Research Council of Dicle University (DUBAP Project) [Veteriner.17.020]en_US
dc.description.sponsorshipAuthors are grateful to Scientific Research Council of Dicle University (DUBAP Project No: Veteriner.17.020) for providing the fund and facilities for this experiment. Presented in abstract form at the 34th World Veterinary Association Congress taking place at the Centre de Convencions Internacional de Barcelona (CCIB) from May 5 to 8, 2018, in Barcelona, Spain. Thanks are due to Ceva Animal Health Inc. Turkey for supplying MB pure substance.en_US
dc.identifier.citationAltan, F., Corum, O., Corum, D. D., Altan, S., Uney, K. (2019). Pharmacokinetics of Marbofloxacin Following Intramuscular Administration at Different Doses in Sheep. Small Ruminant Research, 174, 88-91.
dc.identifier.doi10.1016/j.smallrumres.2019.03.016en_US
dc.identifier.endpage91en_US
dc.identifier.issn0921-4488en_US
dc.identifier.issn1879-0941en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.smallrumres.2019.03.016
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38085
dc.identifier.volume174en_US
dc.identifier.wosWOS:000467890900015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorUney, Kamil.
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofSMALL RUMINANT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMarbofloxacinen_US
dc.subjectPharmacokineticsen_US
dc.subjectDifferent doseen_US
dc.subjectSheepen_US
dc.titlePharmacokinetics of marbofloxacin following intramuscular administration at different doses in sheepen_US
dc.typeArticleen_US

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