Effect of Long-Term Intraperitoneal Zinc Administration on Liver Glycogen Levels in Diabetic Rats Subjected to Acute Forced Swimming

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dc.contributor.authorBicer, Mursel
dc.contributor.authorGunay, Mehmet
dc.contributor.authorAkil, Mustafa
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.date.accessioned2020-03-26T18:14:16Z
dc.date.available2020-03-26T18:14:16Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aims to examine the effect of zinc administration on liver glycogen levels of rats in which diabetes was induced with streptozotocin and which were subjected to acute swimming exercise. The study was conducted on 80 adult Sprague-Dawley male rats, which were equally allocated to eight groups: group 1, general control; group 2, zinc-administrated control; group 3, zinc-administrated diabetic control; group 4, swimming control; group 5, zinc-administrated swimming; group 6, zinc-administrated diabetic swimming; group 7, diabetic swimming; group 8, diabetic control group. In order to induce diabetes, animals were injected with 40 mg/kg intraperitoneal (ip) streptozotocin. The injections were repeated in the same dose after 24 h. Animals which had blood glucose at or above 300 mg/dl 6 days after the last injections were accepted as diabetic. Zinc was administrated ip for 4 weeks as 6 mg/kg/day per rat. Hepatic tissue samples taken from the animals at the end of the study were fixed in 95% ethyl alcohol. Cross sections of 5 A mu m thickness, taken by the help of a microtome from the tissue samples buried in paraffin, were placed on a microscope slide and stained with periodic acid-Schiff and evaluated by light microscope. All microscopic images were transferred to a PC and assessed with the help of Clemex PE3.5 image analysis software. The lowest liver glycogen levels in the study were obtained in groups 3, 4, 6, 7, and 8. Liver glycogen levels in group 5 were higher than groups 3, 4, 6, 7, and 8, but lower than groups 1 and 2 (p < 0.05). Groups 1 and 2 had the highest liver glycogen levels. The results obtained from the study indicate that liver glycogen levels which dropped in acute swimming exercise were restored by zinc administration and that diabetes induced in rats prevented the protective effect of zinc.en_US
dc.identifier.doi10.1007/s12011-010-8658-5en_US
dc.identifier.endpage324en_US
dc.identifier.issn0163-4984en_US
dc.identifier.issue3en_US
dc.identifier.pmid20213347en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12011-010-8658-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26368
dc.identifier.volume139en_US
dc.identifier.wosWOS:000287321900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectZincen_US
dc.subjectDiabetesen_US
dc.subjectAcute swimming exerciseen_US
dc.subjectGlycogenen_US
dc.titleEffect of Long-Term Intraperitoneal Zinc Administration on Liver Glycogen Levels in Diabetic Rats Subjected to Acute Forced Swimmingen_US
dc.typeArticleen_US

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