Erythromycin Inhibits Prostaglandin F2?-İnduced Contractions of Myometrium Isolated From Non-Pregnant Rats

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dc.contributor.authorÇelik, Hüsnü
dc.contributor.authorAyar, Ayar
dc.contributor.authorBaltacı, Abdülkerim
dc.contributor.authorTuğ, Niyazi
dc.date.accessioned2020-03-26T16:45:00Z
dc.date.available2020-03-26T16:45:00Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the effects of erythromycin on prostaglandin F2? (PGF2?)-induced contractions of isolated myometrial strips from non-pregnant rats. Design: In vitro pharmacological study. Setting: Firat University Faculty of Medicine. Sample: Myometrium samples were taken from 55 adult Wistar rats. Methods: Myometrial strips were isolated from mature, non-pregnant Wistar rats. Isometric contractions of these strips were induced with 1 ?M PGF2?. Effects of 0.01, 0.1, 0.2, 0.5 and 1 mM erythromycin on the frequency and amplitude of these PGF2?-induced contractions were recorded. Main outcome measures: The inhibition of prostaglandin F2?-induced contractions in vitro. Results: Application of 0.01 mM erythromycin had no effect on either amplitude or frequency of contractions. However, 0.1, 0.2, 0.5 and 1 mM erythromycin decreased the frequency and amplitude of PGF2?-induced contractions. The inhibitory effect of erythromycin on amplitude was 27%, 38%, 54% and 83% (P < 0.05), and that on frequency was 10%, 16%, 32% and 61% (P < 0.05) at 0.1, 0.2, 0.5 and 1 mM concentrations, respectively. Conclusion: The results of this study demonstrate that erythromycin inhibits PGF2?-induced contractions in rat myometrium. Because PGF2?-induced contractions have been suggested to be involved in the pathogenesis of primary dysmenorrhoea, effects of erythromycin in this clinical entity may present a new approach for the treatment.en_US
dc.identifier.citationÇelik, H., Ayar, A., Baltacı, A., Tuğ, N., (2002). Erythromycin Inhibits Prostaglandin F2?-İnduced Contractions of Myometrium Isolated From Non-Pregnant Rats. BJOG: An International Journal of Obstetrics and Gynaecology, (109), 1036-1040. Doi: 10.1016/S1470-0328(02)01158-8
dc.identifier.doi10.1016/S1470-0328(02)01158-8en_US
dc.identifier.endpage1040en_US
dc.identifier.issn1470-0328en_US
dc.identifier.pmid12269679en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1036en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S1470-0328(02)01158-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18150
dc.identifier.volume109en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaltacı, Abdülkerim
dc.language.isoenen_US
dc.relation.ispartofBJOG: An International Journal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleErythromycin Inhibits Prostaglandin F2?-İnduced Contractions of Myometrium Isolated From Non-Pregnant Ratsen_US
dc.typeArticleen_US

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