Serum C-reactive protein and procalcitonin levels in non-small cell lung cancer patients

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dc.contributor.authorTulek, Baykal
dc.contributor.authorKoylu, Habibe
dc.contributor.authorKanat, Fikret
dc.contributor.authorArslan, Ugur
dc.contributor.authorOzer, Faruk
dc.date.accessioned2020-03-26T18:43:18Z
dc.date.available2020-03-26T18:43:18Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim Of the Study: The basic uses of C-re, active protein (CRP) and procalcitonin (PCT) in clinical practice are in the diagnosis and follow-up of infectious disease. The fact that CRP already achieves high levels in cases with lung cancer, however, limits its diagnostic specificity. Procalcitonin may be an important Marker in the differential diagnosis of lung cancer patients who have fever and high CRP levels. Our Objective in this Study was to determine the levels of CRP and PCT in patients with newly diagnosed noninfectious non-small tell lung cancer (NSCLC) and to relate these results to patient and disease Characteristics. Material and Methods: Serum CRP and PCT levels were Measured in 79 histopathologically proven NSCLC patients and 20 healthy controls. Results were compared with demographic and clinical variables in patients with NSCLC. Results: Serum CRP concentrations were significantly higher in NSCLC patients compared to the Control group [38.30 (7.79-185) mg/dl vs. 7.79 (3.36-26.10) mg/dl; p < 0.001] There was no significant difference between the two groups in PCT levels (p > 0.05). A mild, positive correlation was found between CRP level and tumor diameter. When comparing CRP levels in the lung cancer patients grouped according to age, sex, smoking status, clinical TNM staging and performance status (PS), the only significant difference found was that for PS Score. Conclusions: High serum CRP levels in non-infectious NSCLC patients are mainly related to PS status and weakly to tumor size. Adding serum PCT measurement may contribute to exclusion of infections in patients with NSCLC.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study was supported by a scientific research grant from Selcuk University.en_US
dc.identifier.doi10.5114/wo.2013.33777en_US
dc.identifier.endpage72en_US
dc.identifier.issn1428-2526en_US
dc.identifier.issn1897-4309en_US
dc.identifier.issue1en_US
dc.identifier.pmid23788965en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://dx.doi.org/10.5114/wo.2013.33777
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29806
dc.identifier.volume17en_US
dc.identifier.wosWOS:000316428000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTERMEDIA PUBLISHING HOUSE LTDen_US
dc.relation.ispartofWSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectC-reactive proteinen_US
dc.subjectprocalcitoninen_US
dc.subjectnon-small cell lung canceren_US
dc.subjectinflammationen_US
dc.titleSerum C-reactive protein and procalcitonin levels in non-small cell lung cancer patientsen_US
dc.typeArticleen_US

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