Neurotrophins and neuroinflammation in fetuses exposed to maternal depression and anxiety disorders during pregnancy: a comparative study on cord blood

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dc.contributor.authorAkbaba, Nursel
dc.contributor.authorAnnagur, Bilge Burcak
dc.contributor.authorAnnagur, Ali
dc.contributor.authorAkbulut, Hikmet
dc.contributor.authorAkyurek, Fikret
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T19:54:47Z
dc.date.available2020-03-26T19:54:47Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn recent years, there have been changes in the approach to maternal psychiatric disorders and their effects on the fetus, with the focus redirected to the search for biological markers. Neurotrophic factors and inflammatory processes have received particular attention in the past few years. According to the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), the study sample (n = 136) consisted of three groups: mothers with major depressive disorder (MDD group, n = 25), mothers with anxiety disorder (AD group, n = 18), and mothers without any psychiatric disorders (not diagnosed (ND) group, n = 93). During the delivery/cesarean section, a blood sample was obtained from the umbilical cord. Serum concentrations of BDNF, NT-3, FGF2, TNF-alpha, and neopterin were determined by enzyme-linked immunosorbent assay (ELISA), according to the manufacturer's procedure. Clinical and biochemical characteristics were assessed. We did not find a significant difference among the three study groups with regard to BDNF, NT-3, and TNF-alpha levels. The ANOVA test indicated statistically significant differences in FGF2 levels and neopterin between the study groups. The newborns of mothers with AD had significantly higher FGF2 levels and significantly higher neopterin levels when compared with those of mothers with MDD and healthy mothers. The present study sheds light on the effects of higher FGF2 and neopterin levels in fetuses exposed to AD. Our results should be replicated through further prospective studies with a larger sample size.en_US
dc.identifier.doi10.1007/s00737-017-0774-1en_US
dc.identifier.endpage111en_US
dc.identifier.issn1434-1816en_US
dc.identifier.issn1435-1102en_US
dc.identifier.issue1en_US
dc.identifier.pmid28884439en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage105en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00737-017-0774-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36797
dc.identifier.volume21en_US
dc.identifier.wosWOS:000419890800010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER WIENen_US
dc.relation.ispartofARCHIVES OF WOMENS MENTAL HEALTHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNeurotrophinsen_US
dc.subjectNeuroinflammationen_US
dc.subjectMaternal psychiatric disordersen_US
dc.titleNeurotrophins and neuroinflammation in fetuses exposed to maternal depression and anxiety disorders during pregnancy: a comparative study on cord blooden_US
dc.typeArticleen_US

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