EFFECT OF VASOACTIVE INTESTINAL PEPTIDE (VIP) ON CYTOKINE LEVELS AND HAEMOSTATIC AND BIOCHEMICAL PARAMETERS IN A RAT ENDOTOXAEMIC MODEL

Basit Öğe Kaydı
dc.contributor.authorCol, Ramazan
dc.contributor.authorDurgun, Zafer
dc.date.accessioned2020-03-26T18:25:06Z
dc.date.available2020-03-26T18:25:06Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe presented study was planned to determine whether vasoactive intestinal peptide (VIP) could prevent cytokine haemostatic, haematological, and biochemical disturbances in LPS-treated rats. Adult male Wistar rats (weight range: 200-250 g) were used. The study included four groups: group 1 served as a control group (C); animals in group 2 were given intravenously 1.6 mg/100 g of LPS (E. coli, serotype 0.111:B4); in group 3, rats were injected intraperitoneally with 25 ng/kg of VIP; in group 4, the same doses of VIP and I,PS were injected simultaneously. Blood samples were collected 6 h after treatments. In endotoxaemic rats, platelet count, fibrinogen, and antithrombin levels were decreased, the activated partial thromboplastin time and prothrombin time were prolonged, and leucopoenia, as well as significant changes in differential leukocyte percentage were demonstrated. In addition, LPS caused statistically significant increases in plasma INF-alpha, IL-6, and IL-10 levels, and AST, ALT, creatinine, cholesterol, triglyceride concentrations. However, it caused a statistically significant decrease in total protein and albumin levels when compared to control group. The results showed that during endotoxaemia, VIP had moderately therapeutic effect as an antiinflammatory agent, suppressing INF-alpha and IL-6, and stimulating IL-10; however, it was not effective against the adverse effect of LPS on investigated haematological and biochemical parameters.en_US
dc.description.sponsorshipBAP (Selcuk University, Konya, Turkey)Selcuk University [2003-101]en_US
dc.description.sponsorshipThis study was financed by BAP (2003-101, Selcuk University, Konya, Turkey).en_US
dc.identifier.endpage67en_US
dc.identifier.issn0042-4870en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27958
dc.identifier.volume56en_US
dc.identifier.wosWOS:000302052100012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNATL VETERINARY RESEARCH INSTen_US
dc.relation.ispartofBULLETIN OF THE VETERINARY INSTITUTE IN PULAWYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectraten_US
dc.subjectendotoxinen_US
dc.subjectvasoactive intestinal peptideen_US
dc.subjectcytokineen_US
dc.subjectdisseminated intravascular coagulationen_US
dc.titleEFFECT OF VASOACTIVE INTESTINAL PEPTIDE (VIP) ON CYTOKINE LEVELS AND HAEMOSTATIC AND BIOCHEMICAL PARAMETERS IN A RAT ENDOTOXAEMIC MODELen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu