Relationship between mean platelet volume and low-grade systemic coagulation with vitamin D deficiency in primary ovarian insufficiency

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dc.contributor.authorKebapçılar, Ayşe Gül
dc.contributor.authorKulaksızoğlu, Mustafa
dc.contributor.authorİpekçi, Süleyman Hilmi
dc.contributor.authorKorkmaz, Hüseyin
dc.contributor.authorKebapçılar, Levent
dc.contributor.authorAkyürek, Fikret
dc.contributor.authorTaner, Cüneyt Eftal
dc.date.accessioned2020-03-26T18:43:09Z
dc.date.available2020-03-26T18:43:09Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPremature menopause in young women is associated with an increased incidence of cardiovascular disease. The present study was designed to determine vitamin D (vit D) and the coagulation parameters such as activated partial thromboplastin time (APTT), PT, D-dimer, white blood cell (WBC), and mean platelet volume (MPV) levels, in primary ovarian insufficiency (POI) patients and control women with a normal menstrual cycle. A total of 43 patients with non-diabetic POI were studied in order to evaluate and compare with the control group comprising 33 women with a normal menstrual cycle. There was no significant difference between the groups for age and body mass index (BMI). D-dimer, WBC, MPV, PT, total cholesterol, and LDL cholesterol were higher in women with POI. APTT levels were also increased but missed the significance in POI group. Women with POI had significantly lower serum vit D levels compared with healthy control group. FSH level was positively correlated with D-dimer, WBC, MPV, and negatively correlated to vit D and serum D vit level was inversely correlated with MPV, APTT, D-dimer, FSH levels in individual women. The obtained results seem to indicate that POI patients had low-grade systemic coagulation and fibrinolytic activation as evidenced by elevated D-dimer, WBC, MPV, PT values potentially be used as indicators of risk factor for thrombosis and atherosclerosis in POI women. All of our patients with POI were deficient in vit D. These results also suggest that vit D deficiency plays important roles of POI women and associated with coagulation, independently from age and BMI.en_US
dc.identifier.doi10.1007/s00404-013-2735-xen_US
dc.identifier.endpage212en_US
dc.identifier.issn0932-0067en_US
dc.identifier.issn1432-0711en_US
dc.identifier.issue1en_US
dc.identifier.pmid23377179en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-013-2735-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29777
dc.identifier.volume288en_US
dc.identifier.wosWOS:000320383500029en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectVitamin Den_US
dc.subjectMPVen_US
dc.subjectWBCen_US
dc.subjectD-dimeren_US
dc.subjectAPTTen_US
dc.subjectPTen_US
dc.titleRelationship between mean platelet volume and low-grade systemic coagulation with vitamin D deficiency in primary ovarian insufficiencyen_US
dc.typeArticleen_US

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