New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunion species

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorPaksoy, Mehmet Yavuz
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorGlamocilja, Jasmina
dc.contributor.authorSokovic, Marina
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziáky, Zoltán
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorCustodio, Luisa
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:15:25Z
dc.date.available2020-03-26T20:15:25Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractBunium species have been reported to be used both as food and in traditional medicines. The scientific community has attempted to probe into the pharmacological and chemical profiles of this genus. Nonetheless, many species have not been investigated fully to date. In this study, we determined the phenolic components, antimicrobial, antioxidant, and enzyme inhibitory activities of aerial parts of four Bunium species (B. sayai, B. pinnatifolium, B. brachyactis and B. macrocatpum). Results showed that B. microcarpum and B. pinnatifolium were strong antioxidants as evidenced in the DPPH, ABTS, CUPRAC, and FRAP assays. B. brachyactis was the most effective metal chelator, and displayed high enzyme inhibition against cholinesterase, tyrosinase, amylase, glucosidase, and lipase. The four species showed varied antimicrobial activity against each microorganism. Overall, they showed high activity against P. mirabilis and E. call (MIC and MBC < 1 mg(-1)). B. brachyactis was more effective against Aspergillus versicolor compared to the standard drug ketoconazole. B. brachyactis was also more effective than both ketoconazole and bifonazole against Trichoderma viride. B. sayai was more effective than ketoconazole in inhibiting A. fumigates. B. sayai was most non-toxic to HEK 293 (cellular viability = 117%) and HepG2 (cellular viability = 104%). The highest level of TPC was observed in B. pinnatifolium (35.94 mg GAE g(-1)) while B. microcarpum possessed the highest TFC (39.21 mg RE g(-1)). Seventy four compounds were detected in B. microcarpum, 70 in B. brachyactis, 66 in B. sayai, and 51 in B. pinnatifolium. Quinic acid, chlorogenic acid, pantothenic acid, esculin, isoquercitrin, rutin, apigenin, and scopoletin were present in all the four species. This study showed that the four Bunium species are good sources of biologically active compounds with pharmaceutical and nutraceutical potential.en_US
dc.identifier.citationZengin, G., Paksoy, M. Y., Aumeeruddy, M. Z., Glamocilja, J., Sokovic, M., Diuzheva, A., Jeko, J., Cziaky, Z., Rodrigues, M. J., Custodio, L., Mahomoodally, M. F. (2019). New Insights into the Chemical Profiling, Cytotoxicity and Bioactivity of Four Bunium Species. Food Research International, 123, 414-424.
dc.identifier.doi10.1016/j.foodres.2019.05.013en_US
dc.identifier.endpage424en_US
dc.identifier.issn0963-9969en_US
dc.identifier.issn1873-7145en_US
dc.identifier.pmid31284993en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage414en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.foodres.2019.05.013
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38031
dc.identifier.volume123en_US
dc.identifier.wosWOS:000477091700044en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofFOOD RESEARCH INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBuniumen_US
dc.subjectPhytoconstituentsen_US
dc.subjectCytotoxicityen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitorsen_US
dc.titleNew insights into the chemical profiling, cytotoxicity and bioactivity of four Bunion speciesen_US
dc.typeArticleen_US

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