Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan

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dc.authorid0000-0002-9600-3526
dc.authorid0000-0002-3651-2636
dc.authorid0000-0001-7525-2913
dc.authorid0000-0002-7242-4860
dc.authorid0000-0001-6548-7823
dc.contributor.authorYagi, Sakina
dc.contributor.authorMohammed, Atif B. A.
dc.contributor.authorTzanova, Tzvetomira
dc.contributor.authorSchohn, Herve
dc.contributor.authorAbdelgadir, Haider
dc.contributor.authorStefanucci, Azzurra
dc.contributor.authorMollica, Adriano
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T20:20:10Z
dc.date.available2020-03-26T20:20:10Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractEssential oils from the inflorescence of Cymbopogon schoenanthus and C. nervatus growing in Northern Sudan were examined for their chemical composition, antiproliferative activity against human breast carcinoma and human colon adenocarcinoma cell lines, antioxidant activity (phosphomolybdenum, antiradical, reducing power, and ferrous chelating), and enzyme inhibition activity against acetylcholinesterase butyrylcholinesterase, tyrosinase, alpha-glucosidase, and alpha-amylase. In silico study on the inhibition of tyrosinase and alpha-amylase was also performed. Piperitone (59.1%) and isomers of para-menthadienols (35.3%) were the main compounds in C. schoenanthus and C. nervatus oils, respectively. Oil from C. nervatus possessed higher antioxidant activity than that from C. schoenanthus except for its metal chelating ability. Both oils showed high antiproliferative activity. In silico study showed that trans-p-mentha-2,8-dien-1-ol and piperitone (both isomers) revealed the best docking scores for alpha-amylase and tyrosinase, respectively. In conclusion, oils from these two Cymbopogon species could be new natural agents with functional properties for food, cosmetics, and pharmaceutical industries. Practical applications Recently, there is a growing tendency to replace synthetic oils by natural ones in the cosmetic, food, and pharmaceutical products. In this context, we investigated the chemical characterization and biological activities of two Cymbopogon species essential oils (C. schoenanthus (L.) Spreng. and C. nervatus). Antioxidant capacity, enzyme inhibition, and antiproliferative effects were tested for biological activities. Chemical characterization was identified by GC-MS. Based on our findings, the Cymbopogon species may be utilized as sources of natural bioactive agents in food industries.en_US
dc.identifier.citationYagi, S., Mohammed, A. B. A., Tzanova, T., Schohn, H., Abdelgadir, H., Stefanucci, A., Mollica, A., Zengin, G. (2020). Chemical Profile, Antiproliferative, Antioxidant, and Enzyme Inhibition Activities and Docking Studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan. Journal of Food Biochemistry, 44(2), 1-11.
dc.identifier.doi10.1111/jfbc.13107en_US
dc.identifier.endpage11
dc.identifier.issn0145-8884en_US
dc.identifier.issn1745-4514en_US
dc.identifier.issue2en_US
dc.identifier.pmid31808956en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.1111/jfbc.13107
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38519
dc.identifier.volume44en_US
dc.identifier.wosWOS:000500885300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF FOOD BIOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectantioxidanten_US
dc.subjectantiproliferativeen_US
dc.subjectchemical profileen_US
dc.subjectCymbopogonen_US
dc.subjectenzyme inhibitionen_US
dc.titleChemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudanen_US
dc.typeArticleen_US

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