Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in patients with aggressive periodontitis

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dc.contributor.authorGünpınar, Şadiye Coşkuner
dc.contributor.authorAlptekin, Nilgün Özlem
dc.contributor.authorDündar, Niyazi
dc.date.accessioned2020-03-26T19:41:48Z
dc.date.available2020-03-26T19:41:48Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVES: The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of monocyte chemoattractant protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. MATERIAL AND METHODS: A total of 160 subjects including 80 AgP and 80 age- and gender-matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP, and 80 H. Volume of GCF was measured by Periotron 8000 (R), and enzyme-linked immunosorbent assay was used to assess MCP-1 levels. RESULTS: Compared to H controls, all clinical parameters and total amounts (pg 30 s(-1)) of MCP-1 were significantly higher in subjects with LAgP and GAgP (P < 0.05). Although concentrations of GCF MCP-1 did not differ between LAgP and GAgP (P > 0.05), total amounts of MCP-1 were higher in GAgP than LAgP (P < 0.05). CONCLUSION: It can be concluded that the total amount of MCP-1 level in GCF may be a potential determinant in AgP subjects. Increased MCP-1 levels in line with the degree of periodontal destruction in GAgP patients reveal that MCP-1 can be used to understand the disease pathogenesis of LAgP and GAgP.en_US
dc.description.sponsorshipSelcuk University Scientific Research CenterSelcuk University [11102024]en_US
dc.description.sponsorshipThis study was supported by Selcuk University Scientific Research Center (Project number 11102024).en_US
dc.identifier.doi10.1111/odi.12658en_US
dc.identifier.endpage769en_US
dc.identifier.issn1354-523Xen_US
dc.identifier.issn1601-0825en_US
dc.identifier.issue6en_US
dc.identifier.pmid28231622en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage763en_US
dc.identifier.urihttps://dx.doi.org/10.1111/odi.12658
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35153
dc.identifier.volume23en_US
dc.identifier.wosWOS:000407267500012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofORAL DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectaggressive periodontitisen_US
dc.subjectenzyme-linked immunosorbent assayen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectmonocyte chemoattractant protein-1en_US
dc.titleGingival crevicular fluid levels of monocyte chemoattractant protein-1 in patients with aggressive periodontitisen_US
dc.typeArticleen_US

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