The association between serum angiogenin and osteopontin levels and coronary collateral circulation in patients with chronic total occlusion

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dc.contributor.authorGürses, Kadri Murat
dc.contributor.authorYalçın, Muhammed Ulvi
dc.contributor.authorKoçyiğit, Duygu
dc.contributor.authorBeşler, Muhammed Said
dc.contributor.authorCanpınar, Hande
dc.contributor.authorEvranos, Banu
dc.contributor.authorYorgun, Hikmet
dc.contributor.authorŞahiner, Mehmet Levent
dc.contributor.authorKaya, Ergün Barış
dc.contributor.authorÖzer, Necla
dc.contributor.authorGüç, Dicle
dc.contributor.authorAytemir, Kudret
dc.contributor.authorTokgözoğlu, Lale
dc.date.accessioned2020-03-26T20:19:21Z
dc.date.available2020-03-26T20:19:21Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: A well-developed coronary collateral circulation lowers both in-hospital and long-term morbidity and mortality limiting the infarct. Angiogenin (AGN) and osteopontin (OPN) are known to be potent inducers of angiogenesis. The aim of the present study was to investigate the relationship between serum ANG and OPN levels and collateral filling grade in subjects with stable coronary artery disease (SCAD). Methods: A total of 122 age- and gender-matched consecutive patients who were found to have total occlusion (n=70) and no significant stenosis in epicardial coronary arteries (n=52) who underwent coronary angiography due to SCAD between January 2015 and July 2017 were included in the study. AGN and OPN levels were measured using enzyme-linked immunosorbent assay. Coronary collateral circulation was graded using Rentrop's classification of collateral filling. Results: A total of 52 patients (61.60 +/- 11.78 years, 61.5% male) without significant epicardial coronary artery stenosis and 70 patients (62.87 +/- 8.24 years, 65.7% male) with totally occluded coronary arteries were included in the study. Subjects with total occlusion had significantly higher levels of AGN [122.00 (79.00-623.00) pg/mL vs. 98.00 (18.00-160.00) pg/mL, p<0.0011 and OPN [1863.50 (125.00-6500.00) pg/mL vs. 451.00 (112.00-1850.00) pg/mL, p<0.0011 than those without significant stenosis. In addition, AGN [127.00 (87.00-623.00) pg/mL vs. 110.00 (79.00-188.00) pg/mL, p=0.0111 and OPN [2681.00 (126.00-6500.00) pg/mL vs. 649.00 (125.00-4255.00) pg/mL, p=0.0011 levels were significantly higher in patients with better developed collaterals. Serum AGN and OPN levels were found to be significantly associated with coronary collateral development. Conclusion: AGN and OPN are associated with better developed coronary collateral circulation and may have therapeutic implications for the promotion of coronary collateral development.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination UnitHacettepe University [845]en_US
dc.description.sponsorshipThis research was supported by Hacettepe University Scientific Research Projects Coordination Unit (project no.: 845).en_US
dc.identifier.citationGürses, K. M., Yalçın, M. U., Koçyiğit, D., Beşler, M.S., Canpınar, H., Evranos, B., Yorgun, H., Şahiner, M. L., Kaya, E. B., Özer, N., Güç, D., Aytemir, K., Tokgözoğlu, L. (2019). The Association Between Serum Angiogenin And Osteopontin Levels And Coronary Collateral Circulation İn Patients With Chronic Total Occlusion. Anatolıan Journal Of Cardıology, 22,(2), 77-84.
dc.identifier.doi10.14744/AnatolJCardiol.2019.88555en_US
dc.identifier.endpage84en_US
dc.identifier.issn2149-2263en_US
dc.identifier.issn2149-2271en_US
dc.identifier.issue2en_US
dc.identifier.pmid31375653en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://dx.doi.org/10.14744/AnatolJCardiol.2019.88555
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38229
dc.identifier.volume22en_US
dc.identifier.wosWOS:000482646600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYalçın, Muhammed Ulvi
dc.language.isoenen_US
dc.publisherTURKISH SOC CARDIOLOGYen_US
dc.relation.ispartofANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcoronary collateral circulationen_US
dc.subjectosteopontinen_US
dc.subjectangiogeninen_US
dc.titleThe association between serum angiogenin and osteopontin levels and coronary collateral circulation in patients with chronic total occlusionen_US
dc.typeArticleen_US

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