Protective effect of pentoxifylline on growth plate in neonatal rats following long-term phototherapy

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorPirgon, Ozgur
dc.contributor.authorEsen, H. Hasan
dc.date.accessioned2020-03-26T17:17:59Z
dc.date.available2020-03-26T17:17:59Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe demonstrated previously that receiving long-term phototherapy was associated with early impairment of growth plate structure in neonatal rats, and oxidative stress may be the main risk factor for growth plate injury. The purpose of this study was to examine the histomorphometric effects of pentoxifylline treatment on the growth plate. Sixty weanling Sprague-Dawley rats were randomly separated into three equal groups. Group A, the control group, did not receive phototherapy and pentoxifylline. Groups B and C were exposed to phototherapy for 7 d. In addition to phototherapy, group C was also given pentoxifylline during the study period. Compared with zonal lengths on d 7 after initiation of phototherapy, group B had significantly lower values than group A for all zonal lengths (p < 0.001). Zonal lengths of growth plate were increased significantly with pentoxifylline treatment in group C for 7 d compared with group B (p < 0.001). After phototherapy, group B had significantly higher values than groups A and C for plasma malondialdehyde levels (p < 0.001). The pentoxifylline was found here to have some potential to reduce the effects of phototherapy on growth plate in neonatal rats at a relatively low dose.en_US
dc.identifier.doi10.1203/PDR.0b013e3180a725c3en_US
dc.identifier.endpage166en_US
dc.identifier.issn0031-3998en_US
dc.identifier.issue2en_US
dc.identifier.pmid17597644en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://dx.doi.org/10.1203/PDR.0b013e3180a725c3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21554
dc.identifier.volume62en_US
dc.identifier.wosWOS:000248339700009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINT PEDIATRIC RESEARCH FOUNDATION, INCen_US
dc.relation.ispartofPEDIATRIC RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleProtective effect of pentoxifylline on growth plate in neonatal rats following long-term phototherapyen_US
dc.typeArticleen_US

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