Amelioration of radiation-induced lung injury by halofuginone: An experimental study in Wistar-Albino rats

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dc.contributor.authorCalik, M.
dc.contributor.authorYavas, G.
dc.contributor.authorCalik, S. G.
dc.contributor.authorYavas, C.
dc.contributor.authorCelik, Z. E.
dc.contributor.authorSargon, M. F.
dc.contributor.authorEsme, H.
dc.date.accessioned2020-03-26T19:33:44Z
dc.date.available2020-03-26T19:33:44Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTo evaluate effects of halofuginone (H) on radiation-induced lung injury (RILI), 60 rats were divided into six groups: Group (G) 1 control, G2 radiotherapy (RT) only, G3 and G4 2. 5 and 5 g H and G5 and G6 RT + 2.5 and 5 g H groups, respectively. A single dose of 12 Gy RT was given to both lungs. H was applied intraperitoneally with daily doses, until animals were killed at 6 and 16 weeks after RT. At 6th and 16th weeks of RT, five rats from each group were killed. Lung tissues were dissected for light and electron microscopy. Chronic inflammation, fibrosis and transforming growth factor-beta (TGF)- scores of all study groups were significantly different at 6th and 16th week (p < 0.001). Chronic inflammation, fibrosis and TGF- scores of G2 were higher than G5 and G6 at 6th and 16th weeks of RT. At 16th week, fibrosis and TGF- scores of G5 were higher than G6 (p = 0.040 and 0.028, respectively). Electron microscopical findings also supported these results. Therefore, H may ameliorate RILI. The effect of the H was more prominent at higher dose and after long-term follow-up. These findings should be clarified with further studies.en_US
dc.description.sponsorshipKonya Training and Research HospitalKonya Egitim Training & Research Hospitalen_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Konya Training and Research Hospital.en_US
dc.identifier.doi10.1177/0960327116660753en_US
dc.identifier.endpage647en_US
dc.identifier.issn0960-3271en_US
dc.identifier.issn1477-0903en_US
dc.identifier.issue6en_US
dc.identifier.pmid27457799en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage638en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0960327116660753
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34776
dc.identifier.volume36en_US
dc.identifier.wosWOS:000402150300011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofHUMAN & EXPERIMENTAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHalofuginoneen_US
dc.subjectfibrosisen_US
dc.subjectpulmonary toxicityen_US
dc.subjectradiotherapyen_US
dc.titleAmelioration of radiation-induced lung injury by halofuginone: An experimental study in Wistar-Albino ratsen_US
dc.typeArticleen_US

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