Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zinc

Basit Öğe Kaydı
dc.contributor.authorBaltaci, A. K.
dc.contributor.authorMogulkoc, R.
dc.contributor.authorAyyildiz, M.
dc.contributor.authorKafali, E.
dc.contributor.authorKoyuncouglu, T.
dc.date.accessioned2020-03-26T18:51:22Z
dc.date.available2020-03-26T18:51:22Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of the present study was to determine the effect of zinc supplementation and zinc deficiency on the lipid peroxidation in the testis and kidney tissues of rats with experimentally induced hypothyroidism. The experimental Groups were formed as follows: 1 - Control; 2 - Sham-Hypothyroidism; 3 - Hypothyroidism (intraperitoneal administration of 10 mg/kg/day PTU for 4 weeks); 4 Hypothyroidism + 3 mg/kg/day zinc supplementation (4 weeks); 5 Hypothyroidism + zinc deficiency (4 weeks). The examination of the study results revealed that hypothyroidism in testis and kidney tissues increased MDA levels and decreased GSH levels (p<0.001). Zinc supplementation in addition to hypothyroidism, however, reduced the increased MDA amount and elevated GSH levels (p<0.001). Zinc deficiency together with hypothyroidism, on the other hand, was found to produce the opposite results (p<0.001). The results of the study indicated that experimental hypothyroidism caused lipid peroxidation in kidney and testis tissues. Zinc deficiency together with hypothyroidism made lipid peroxidation more evident, while zinc supplementation significantly inhibited the increased oxidative stress by activating the antioxidant system (Tab. 1, Ref. 24). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipSUBAPK (Scientific Research Project Coordinator of Selcuk University)Selcuk University [TF 2002-086]en_US
dc.description.sponsorshipThis study was supported in part by SUBAPK (Scientific Research Project Coordinator of Selcuk University). Project number is TF 2002-086.en_US
dc.identifier.doi10.4149/BLL_2014_097en_US
dc.identifier.endpage501en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue8en_US
dc.identifier.pmid25246287en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage498en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2014_097
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30967
dc.identifier.volume115en_US
dc.identifier.wosWOS:000342185000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthypothyroidismen_US
dc.subjectkidneyen_US
dc.subjecttestesen_US
dc.subjectMDAen_US
dc.subjectGSHen_US
dc.subjectzincen_US
dc.titleLipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zincen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu