Effects of diode laser application on inflammation and mpo in periodontal tissues in a rat model

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dc.authorid0000-0002-9707-1379
dc.contributor.authorUslu, Mustafa Ozay.
dc.contributor.authorEltas, Abubekir.
dc.contributor.authorMarakoglu, Ismail.
dc.contributor.authorDundar, Serkan.
dc.contributor.authorSahin, Kazim.
dc.contributor.authorOzercan, Ibrahim Hanifi.
dc.date.accessioned2020-03-26T19:53:40Z
dc.date.available2020-03-26T19:53:40Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractObjective: In this study, we aimed to histologically and immunologically evaluate the effect of diode laser treatment when applied adjunctive to scaling and root planing (SRP) in an experimental periodontitis model. Materials and methods: We used Wistar-Albino rats (n=60) with average weight of 230 g. Experimental periodontitis was induced by ligature at the right and left first mandibular molar teeth in all rats. After 11 days, the ligature was removed and rats were divided into two groups. The control group (n=30) received only SRP treatment, while the laser group (n=30) received a diode laser (GaAlAs, 810 nm, 1 W, 10 J, 20 s) treatment adjunctive to SRP. Ten rats in each group were sacrificed after 7, 15, and 30 days. Histopathological examination was performed in the left mandible of rats. Myeloperoxidase (MPO) was evaluated by western blot in the gingival specimens from the right mandible. Results: MPO levels in the laser group were statistically significantly lower compared with the control group (p <= 0.05). There was no statistically significance at any time between MPO levels in the control group (p>0.05). MPO levels in the laser group at the 7th day were statistically significantly higher compared to the 15th (p <= 0.05) and the 30th day (p <= 0.05). Inflammatory cell infiltration decreased over time in both groups and was statistically significantly lower in the laser group than in the control group at all times (p <= 0.01). Conclusions: Within the limits of this study, we suggest that diode laser application is an adjunctive treatment because it reduced inflammation and MPO when applied in addition to SRP. On the other hand, more studies are needed for the assessment of the effects of diode laser application to periodontal tissues.en_US
dc.description.sponsorshipScientific Research Support Foundation of Inonu University, Malatya, Turkey [2013/90]en_US
dc.description.sponsorshipThis study was financially supported by the Scientific Research Support Foundation of Inonu University, Malatya, Turkey, under project number 2013/90. The authors kindly thank Mehmet Tuzcu, Department of Molecular Biology, Firat University, Elazig, Turkey, for technical support in laboratory procedures. The authors declare that they have no conflict of interest related to this study.en_US
dc.identifier.citationUslu, M. Ö., Eltas, A., Marakoğlu, İ., Dündar, S., Şahın, K., Özercan, İ.H. (2018). Effects of Diode Laser Application on İnflammation and Mpo in Periodontal Tissues in A Rat Model. Journal of Applied Oral Science, 26, 1-13.
dc.identifier.doi10.1590/1678-7757-2017-0266en_US
dc.identifier.endpage13
dc.identifier.issn1678-7757en_US
dc.identifier.issn1678-7765en_US
dc.identifier.pmid30020350en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.1590/1678-7757-2017-0266
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36562
dc.identifier.volume26en_US
dc.identifier.wosWOS:000439207700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMarakoglu, Ismail.
dc.language.isoenen_US
dc.publisherUNIV SAO PAULO FAC ODONTOLOGIA BAURUen_US
dc.relation.ispartofJOURNAL OF APPLIED ORAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectExperimental periodontitisen_US
dc.subjectInflammation and innate immunityen_US
dc.subjectLaseren_US
dc.subjectNon-surgical periodontal therapyen_US
dc.titleEffects of diode laser application on inflammation and mpo in periodontal tissues in a rat modelen_US
dc.typeArticleen_US

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