Does the imbalance between agonistic and antagonistic IL-1 play a role in progression of febrile convulsions?

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dc.contributor.authorOzen, F.
dc.contributor.authorKocak, N.
dc.contributor.authorYildirim, I. Halil
dc.contributor.authorHacimuto, G.
dc.contributor.authorSen, V.
dc.date.accessioned2020-03-26T19:23:39Z
dc.date.available2020-03-26T19:23:39Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: Inflammation may play an important role in the etiopathology of febrile convulsions (FC). IL-1 beta is an important mediator of inflammation and fever is also important information of FCs. It is suggested that there may be a relationship between polymorphisms of IL-1 beta and FC. The aim of the present study is to investigate the polymorphic stituation of promoter region of IL-1 beta in two sites (-31 and -511) and assess the IL-1 RA VNTR polymorphisms in FC patients in comparison with healthy control groups. MATERIALS AND METHODS: Fifty FC patients and 50 healthy controls (HC) were included in the study. DNA extraction was performed by QIAamp DNA Mini Kit from peripheral blood lymphocytes of all subjects. IL-1 beta promoter polymorphisms were analyzed by PCR-RFLP, IL-1 RA VNTR polymorphisms were analyzed by PCR-agarose gel electrophoresis. RESULTS: Genotype distribution of IL-1 beta promoter region in position -31 was statistically different between FC patients and control groups. Allele I and allele II of IL-1 RA distribution were also statistically different in FC patients and healthy controls. CONCLUSIONS: We have found a significant association between IL-1 RA allele distribution and FC and a poor correlation of T/C substitution at the -31 position of IL-1 beta promoter in FC. Further studies are needed to investigate the gene expression levels and polymorphic situation in same samples.en_US
dc.identifier.endpage124en_US
dc.identifier.issn1128-3602en_US
dc.identifier.issue1en_US
dc.identifier.pmid26813462en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33460
dc.identifier.volume20en_US
dc.identifier.wosWOS:000369544000019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVERDUCI PUBLISHERen_US
dc.relation.ispartofEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFebrile Convulsionsen_US
dc.subjectInterleukin-1 betaen_US
dc.subjectPromoteren_US
dc.subjectPolymorphismen_US
dc.subjectIL 1-RAen_US
dc.titleDoes the imbalance between agonistic and antagonistic IL-1 play a role in progression of febrile convulsions?en_US
dc.typeArticleen_US

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