Prolonged QT Dispersion in the Infants of Diabetic Mothers

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dc.contributor.authorArslan, Derya
dc.contributor.authorGuvenc, Osman
dc.contributor.authorCimen, Derya
dc.contributor.authorUlu, Havva
dc.contributor.authorOran, Bulent
dc.date.accessioned2020-03-26T18:58:26Z
dc.date.available2020-03-26T18:58:26Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMyocardial hypertrophy and cardiac dysfunction frequently occur in newborns of diabetic mothers. The authors hypothesized that wall hypertrophy or disproportionate left ventricular wall thickness in newborns of diabetic mothers may affect both QT and QTc dispersion. This study aimed to assess whether left ventricular hypertrophy affects the QT variables of infants born to diabetic mothers. This prospective cross-sectional study was conducted with 47 consecutively selected neonates of gestational diabetic mothers and 30 healthy neonates born to healthy mothers. All the subjects were evaluated during the neonatal period. Electrocardiography with echocardiography was performed for the patients and the control subjects. The newborns of the diabetic mothers were classified according to septal thickness as group 1 (16 newborns with septal hypertrophy) or group 2 (31 newborns without septal hypertrophy). The study group consisted of three cohorts: groups 1, 2, and 3 (control group). Both QT and QTc dispersion were computed from a randomly selected beat as well as from an average beat derived from 12 beats included in a 10-s electrocardiography. A total of 16 infants (34 %) had a septal thickness of 6 mm or greater. The left ventricular end-systolic diameter in group 1 was smaller (p = 0.0029) than in groups 2 and 3 (p = 0.003). The interventricular septal thickness at end diastole (IVSTd) and the left ventricular posterior wall thickness at end diastole in group 1 were higher than in of groups 2 and 3. The QT and QTc dispersion intervals were longer in group 1 than in groups 2 and 3 (p < 0.001), and a highly significant positive correlation was detected between IVSTd and QT dispersion (r = 0.514, p = 0.042). Elevated QT and QTc dispersions may be risk factors for the development of arrhythmias in newborns of diabetic mothers. These patients may critically need systematic cardiac screening.en_US
dc.identifier.doi10.1007/s00246-014-0897-3en_US
dc.identifier.endpage1056en_US
dc.identifier.issn0172-0643en_US
dc.identifier.issn1432-1971en_US
dc.identifier.issue6en_US
dc.identifier.pmid24740627en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1052en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00246-014-0897-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31093
dc.identifier.volume35en_US
dc.identifier.wosWOS:000339112400023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPEDIATRIC CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMaternal diabetes mellitusen_US
dc.subjectQT dispersionen_US
dc.subjectArrhythmiaen_US
dc.subjectNewbornen_US
dc.titleProlonged QT Dispersion in the Infants of Diabetic Mothersen_US
dc.typeArticleen_US

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