Effects of Enrofloxacin, Flunixin and Dexamethasone on Indicators of Oxidative and Organ Damage in Lipopolysaccharide-Induced Endotoxemia

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dc.contributor.authorEr, Ayşe
dc.contributor.authorAltan, Feray
dc.contributor.authorÇetin, Gül
dc.contributor.authorÜney, Kamil
dc.contributor.authorTraş, Bünyamin
dc.contributor.authorElmas, Muammer
dc.contributor.authorYazar, Enver
dc.date.accessioned2020-03-26T17:48:13Z
dc.date.available2020-03-26T17:48:13Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effects of enrofloxacin., flunixin meglumine and dexamethasone on antioxidant status and markers of organ damage in endotoxemia. Rats were divided into four groups. The groups received the following drugs (simultaneously with lipopolysaccharide): enrofloxacin, flunixin meglumine, low-dose dexamethasone or high-dose dexamethasone, respectively. After the treatments, serum and plasma samples were collected at 1, 2, 4, 6, 8, 12, 24 and 48 h. The levels of malondialdehyde, nitric oxide, superoxide dismutase, vitamin C and 13,14-dihydro-15-keto-prostaglandin F-2 alpha were determined with ELISA. The cardiac, hepatic and renal damage markers were measured with autoanalyzer. Elevated levels of malondialdehyde were relatively inhibited by high-dose dexamethasone. Increases in the levels of nitric oxide were inhibited by low and high-dose dexamethasone while increases in the level of 13,14-dihydro-15-keto prostaglandin F-2 alpha were inhibited by all treatments except enrofloxacin. No treatments inhibited the decrease in vitamin C levels. Cardiac and hepatic damage was not inhibited completely whereas renal damage was inhibited by treatment with low or high-dose dexamethasone. The results show that although low-dose dexamethasone had antioxidant activity and protected against organ damage, high-dose dexamethasone may be more beneficial in the treatment of endotoxemia.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107O042]; SUBAPKSelcuk University [08401001]en_US
dc.description.sponsorshipThis study was a part of project that supported by The Scientific and Technological Research Council of Turkey (TUBITAK, 107O042) and SUBAPK (08401001).en_US
dc.identifier.citationEr, A., Altan, F., Çetin, G., Üney, K., Traş, B., Elmas, M., Yazar, E., (2010). Effects of Enrofloxacin, Flunixin and Dexamethasone on Indicators of Oxidative and Organ Damage in Lipopolysaccharide-Induced Endotoxemia. Journal of Animal and Veterinary Advances, 9(10), 1495-1500.
dc.identifier.endpage1500en_US
dc.identifier.issn1680-5593en_US
dc.identifier.issn1993-601Xen_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1495en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24845
dc.identifier.volume9en_US
dc.identifier.wosWOS:000279573300021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorEr, Ayşe
dc.institutionauthorÜney, Kamil
dc.institutionauthorTraş, Bünyamin
dc.institutionauthorElmas, Muammer
dc.institutionauthorYazar, Enver
dc.language.isoenen_US
dc.publisherMedwell Onlineen_US
dc.relation.ispartofJournal of Animal and Veterinary Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndotoxemiaen_US
dc.subjectOxidative stressen_US
dc.subjectOrgan damageen_US
dc.subjectEnrofloxacinen_US
dc.subjectFlunixinen_US
dc.subjectDexamethasoneen_US
dc.titleEffects of Enrofloxacin, Flunixin and Dexamethasone on Indicators of Oxidative and Organ Damage in Lipopolysaccharide-Induced Endotoxemiaen_US
dc.typeArticleen_US

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