Tissue damage in kidney, adrenal glands and diaphragm following extracorporeal shock wave lithotripsy

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dc.contributor.authorGecit, Ilhan
dc.contributor.authorKavak, Servet
dc.contributor.authorOguz, Elif Kaval
dc.contributor.authorPirincci, Necip
dc.contributor.authorGunes, Mustafa
dc.contributor.authorKara, Mikail
dc.contributor.authorCeylan, Kadir
dc.date.accessioned2020-03-26T18:58:42Z
dc.date.available2020-03-26T18:58:42Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was designed to investigate whether exposure to short-term extracorporeal shock wave lithotripsy (ESWL) produces histologic changes or induces apoptosis in the kidney, adrenal glands or diaphragm muscle in rats. The effect of shock waves on the kidney of male Wistar rats (n = 12) was investigated in an experimental setting using a special ESWL device. Animals were killed at 72 h after the last ESWL, and the tissues were stained with an in situ Cell Death Detection Kit, Fluorescein. Microscopic examination was performed by fluorescent microscopy. Apoptotic cell deaths in the renal tissue were not observed in the control group under fluorescent microscopy. In the ESWL group, local apoptotic changes were observed in the kidney in the area where the shock wave was focused. The apoptotic cell deaths observed in the adrenal gland of the control group were similar to those observed in the ESWL groups, and apoptosis was occasionally observed around the capsular structure. Apoptotic cell deaths in the diaphragm muscle were infrequently observed in the control group. Apoptosis in the ESWL group was limited to the mesothelial cells. This study demonstrated that serious kidney, adrenal gland and diaphragm muscles damage occurred following ESWL, which necessitated the removal of the organ in the rat model. It is recognized that the ESWL complications related to the kidney, adrenal gland and diaphragm muscles are rare and may be managed conservatively.en_US
dc.identifier.doi10.1177/0748233712462481en_US
dc.identifier.endpage850en_US
dc.identifier.issn0748-2337en_US
dc.identifier.issn1477-0393en_US
dc.identifier.issue9en_US
dc.identifier.pmid23095486en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage845en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0748233712462481
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31249
dc.identifier.volume30en_US
dc.identifier.wosWOS:000342991800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.ispartofTOXICOLOGY AND INDUSTRIAL HEALTHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectESWLen_US
dc.subjectapoptosisen_US
dc.subjectkidneyen_US
dc.subjectadrenal glanden_US
dc.subjectdiaphragm musclesen_US
dc.titleTissue damage in kidney, adrenal glands and diaphragm following extracorporeal shock wave lithotripsyen_US
dc.typeArticleen_US

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