PAX9 Polymorphisms and susceptibility with sporadic tooth agenesis in Turkish populations: a case-control study

Basit Öğe Kaydı
dc.contributor.authorIsman, Eren
dc.contributor.authorNergiz, Suleyman
dc.contributor.authorAcar, Hasan
dc.contributor.authorSari, Zafer
dc.date.accessioned2020-03-26T18:42:49Z
dc.date.available2020-03-26T18:42:49Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Hypodontia, the congenital absence of one or a few teeth is one of the most common alterations of the human dentition. Familial hypodontia is caused by mutations in PAX9, Msx1 and Axin2 genes. Limited numbers of studies are present to show etiological factors beyond this anomaly in Turkish community belonging to Caucasian racial family. The purpose of this study is to investigate the relationships between the two different single nucleotide polymorphisms that are G-1031A and T-912C with hypodontia in Caucasians. 200 individuals having hypodontia and 114 normal individuals having all 32 teeth present were selected for the study. Blood samples were collected from each individual and DNA was extracted. To determine the polymorphisms, PCR-RFLP method was used. Results: The outcomes suggest that the individuals having AC haplotype carry less risk in having hypodontia compared with the rest of the haplotype groups (OR = 3.88; CI = 95%; p = 0.001). The ratio of GT haplotype is less in the hypodontia group meaning that the GT carriers are in risk group in terms of hypodontia risk. Conclusion: These results indicate that polymorphisms in the promoter region of PAX9 gene may have an influence on the transcriptional factors and activity of this gene and are associated with hypodontia in Caucasian individuals.en_US
dc.description.sponsorshipSelcuk University Scientific Research Project DepartmentSelcuk University [08202020]en_US
dc.description.sponsorshipThis study was supported by Selcuk University Scientific Research Project Department [grant number 08202020].en_US
dc.identifier.doi10.1186/1471-2164-14-733en_US
dc.identifier.issn1471-2164en_US
dc.identifier.pmid24160254en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1186/1471-2164-14-733
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29714
dc.identifier.volume14en_US
dc.identifier.wosWOS:000328635100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBIOMED CENTRAL LTDen_US
dc.relation.ispartofBMC GENOMICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPAX9en_US
dc.subjectHypodontiaen_US
dc.subjectTooth agenesisen_US
dc.subjectOral geneticsen_US
dc.subjectPolymorphismen_US
dc.subjectRFLPen_US
dc.titlePAX9 Polymorphisms and susceptibility with sporadic tooth agenesis in Turkish populations: a case-control studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu