Impact of having family history of psoriasis or psoriatic arthritis on psoriatic disease

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dc.contributor.authorSolmaz, Dilek
dc.contributor.authorBakırcı, Sibel
dc.contributor.authorKimyon, Gezmiş
dc.contributor.authorGünal, Esen K.
dc.contributor.authorDoğru, Atalay
dc.contributor.authorBayındır, Özün
dc.contributor.authorDalkılıç, Ediz
dc.contributor.authorÖzişler, Cem
dc.contributor.authorCan, Meryem
dc.contributor.authorAkar, Servet
dc.contributor.authorÇetin, Gözde Yıldırım
dc.contributor.authorYavuz, Şule
dc.contributor.authorKılıç, Levent
dc.contributor.authorTarhan, Emine F.
dc.contributor.authorKüçükşahin, Orhan
dc.contributor.authorOmma, Ahmet
dc.contributor.authorGönüllü, Emel
dc.contributor.authorYıldız, Fatih
dc.contributor.authorErsözlü, Emine D.
dc.contributor.authorÇınar, Muhammet
dc.contributor.authorAl-Onazi, Atallah
dc.contributor.authorErden, Abdulsamet
dc.contributor.authorTufan, Müge A.
dc.contributor.authorYılmaz, Sema
dc.contributor.authorPehlevan, Seval
dc.contributor.authorKalyoncu, Umut
dc.contributor.authorAydın, Sibel Z.
dc.date.accessioned2020-03-26T20:20:19Z
dc.date.available2020-03-26T20:20:19Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective Psoriatic arthritis (PsA) has a genetic background. Approximately 40% of patients with psoriasis or PsA have a family history of psoriasis or PsA, which may affect disease features. The aim of this study was to assess the effects of family history of psoriasis and PsA on disease phenotypes. Methods Data from 1,393 patients recruited in the longitudinal, multicenter Psoriatic Arthritis International Database were analyzed. The effects of family history of psoriasis and/or PsA on characteristics of psoriasis and PsA were investigated using logistic regression. Results A total of 444 patients (31.9%) had a family history of psoriasis and/or PsA. These patients were more frequently women, had earlier onset of psoriasis, more frequent nail disease, enthesitis, and deformities, and less frequently achieved minimal disease activity. Among 444 patients, 335 only had psoriasis in their family, 74 had PsA, and 35 patients were not certain about having PsA and psoriasis in their family, so they were excluded from further analysis. In the multivariate analysis, family history of psoriasis was associated with younger age at onset of psoriasis (odds ratio [OR] 0.976) and presence of enthesitis (OR 1.931), whereas family history of PsA was associated with lower risk of plaque psoriasis (OR 0.417) and higher risk of deformities (OR 2.557). Family history of PsA versus psoriasis showed increased risk of deformities (OR 2.143) and lower risk of plaque psoriasis (OR 0.324). Conclusion Family history of psoriasis and PsA impacts skin phenotypes, musculoskeletal features, and disease severity. The link between family history of psoriasis/PsA and pustular/plaque phenotypes may point to a different genetic background and pathogenic mechanisms in these subsets.en_US
dc.description.sponsorshipTurkish Society for Rheumatology; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipSupported by the Turkish Society for Rheumatology. Dr. Bakirci's work was supported by the Scientific and Technological Research Council of Turkey and the Turkish Society for Rheumatology.en_US
dc.identifier.citationSolmaz, D., Bakırcı, S., Kimyon, G., Günal, E.K., Doğru, A., Bayındır, Ö., Dalkılıç, E., Özişler, C., Can, M., Akar. S., Yıldırım Çetin, G., Yavuz. Ş., Kılıç, L., F. Tarhan, E., Küçükşahin, O., Omma, A., Gönüllü, E., Yıldız, F., D. Ersözlü, E., Çınar, M., Al-Onazi, A., Erden, A., A. Tufan, M., Yılmaz, S., Pehlevan, S., Kalyoncu, U., Z. Aydın, S. (2020). Impact of Having Family History of Psoriasis or Psoriatic Arthritis on Psoriatic Disease. Arthrıtıs Care& Research, 72,(1), 63-68.
dc.identifier.doi10.1002/acr.23836en_US
dc.identifier.endpage68en_US
dc.identifier.issn2151-464Xen_US
dc.identifier.issn2151-4658en_US
dc.identifier.issue1en_US
dc.identifier.pmid30680951en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://dx.doi.org/10.1002/acr.23836
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38557
dc.identifier.volume72en_US
dc.identifier.wosWOS:000505281300007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Sema
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofARTHRITIS CARE & RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleImpact of having family history of psoriasis or psoriatic arthritis on psoriatic diseaseen_US
dc.typeArticleen_US

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