The Effect of Estradiol and Progesterone Application on Leptin Concentration in Ovariectomized Rats
Yükleniyor...
Dosyalar
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of the present study was to investigate the effects of estradiol and progesterone application on leptin secretion in ovariectomised rats. The study included 30 adult female Sprague-Dawley rats. Rats were divided into three groups as follows:Group 1; Sham ovariectomy group (n=10), Group 2; Ovariectomy group (n=10), Group 3; Ovariectomized and estradiol propionate (450 ?g/kg rat) and medroxyprogesterone acetate (15 mg/kg rat) supplemented group (n=10). One week after ovariectomy, rats in Group 3 were injected estradiol and progesterone for 4 weeks. Twenty-four hours after the last injection, rats were decapitated and blood samples were collected for leptin analysis. Serum leptin levels in Group 2 were found significantly higher than those in Groups 1 and 3 (p<0.01), while those in Group 3 were significantly lower when compared to Group 1 (p<0.01). The findings of the present study have shown that ovariectomy led to a significant increase in leptin levels. However, administration of estradiol and progesterone in combination following ovariectomy inhibites increases of leptin levels.
Açıklama
Anahtar Kelimeler
Estradiol application, Leptin, Ovariectomy, Progesterone application, Rat
Kaynak
Acta Physiologica Hungarica
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
92
Sayı
1
Künye
Öztekin, E., Moğulkoç, R., Baltacı, A. K., Tiftik, A. M., (2005). The Effect of Estradiol and Progesterone Application on Leptin Concentration in Ovariectomized Rats. Acta Physiologica Hungarica, 92(1), 27-31.
