The Effect of Estradiol and Progesterone Application on Leptin Concentration in Ovariectomized Rats

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dc.contributor.authorÖztekin, E.
dc.contributor.authorMoğulkoç, R.
dc.contributor.authorBaltacı, A. K.
dc.contributor.authorTiftik, A. M.
dc.date.accessioned2020-03-26T16:58:58Z
dc.date.available2020-03-26T16:58:58Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the effects of estradiol and progesterone application on leptin secretion in ovariectomised rats. The study included 30 adult female Sprague-Dawley rats. Rats were divided into three groups as follows:Group 1; Sham ovariectomy group (n=10), Group 2; Ovariectomy group (n=10), Group 3; Ovariectomized and estradiol propionate (450 ?g/kg rat) and medroxyprogesterone acetate (15 mg/kg rat) supplemented group (n=10). One week after ovariectomy, rats in Group 3 were injected estradiol and progesterone for 4 weeks. Twenty-four hours after the last injection, rats were decapitated and blood samples were collected for leptin analysis. Serum leptin levels in Group 2 were found significantly higher than those in Groups 1 and 3 (p<0.01), while those in Group 3 were significantly lower when compared to Group 1 (p<0.01). The findings of the present study have shown that ovariectomy led to a significant increase in leptin levels. However, administration of estradiol and progesterone in combination following ovariectomy inhibites increases of leptin levels.en_US
dc.identifier.citationÖztekin, E., Moğulkoç, R., Baltacı, A. K., Tiftik, A. M., (2005). The Effect of Estradiol and Progesterone Application on Leptin Concentration in Ovariectomized Rats. Acta Physiologica Hungarica, 92(1), 27-31.
dc.identifier.doi10.1556/APhysiol.92.2005.1.4en_US
dc.identifier.endpage31en_US
dc.identifier.issn0231-424Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid16003942en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://dx.doi.org/10.1556/APhysiol.92.2005.1.4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20046
dc.identifier.volume92en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Physiologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEstradiol applicationen_US
dc.subjectLeptinen_US
dc.subjectOvariectomyen_US
dc.subjectProgesterone applicationen_US
dc.subjectRaten_US
dc.titleThe Effect of Estradiol and Progesterone Application on Leptin Concentration in Ovariectomized Ratsen_US
dc.typeArticleen_US

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