Successful Engraftment of Donor Marrow After Allogeneic Hematopoietic Cell Transplantation in Autosomal-Recessive Hyper-Ige Syndrome Caused by Dedicator of Cytokinesis 8 Deficiency

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dc.contributor.authorMcDonald, Douglas R.
dc.contributor.authorMassaad, Michel J.
dc.contributor.authorJohnston, Alicia
dc.contributor.authorKeleş, Sevgi
dc.contributor.authorChatila, Talal
dc.contributor.authorGeha, Raif S.
dc.contributor.authorPai, Sung-Yun
dc.date.accessioned2020-03-26T18:05:03Z
dc.date.available2020-03-26T18:05:03Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe hyper-IgE syndromes are rare combined immune deficiencies associated with marked elevations in plasma IgE levels and eosinophilia. An autosomal-dominant form of hyperIgE syndrome caused by mutations in signal transducer and activator of transcription 3 is characterized by elevated IgE, eosinophilia, eczema, recurrent skin and pulmonary infections, and skeletal abnormalities.1 Recently, an autosomal recessive form of hyper-IgE syndrome caused by mutations in the dedicator of cytokinesis 8 (DOCK8) gene has been identified and is characterized by elevated IgE levels, eosinophilia, atopic dermatitis, asthma, food allergies, recurrent upper and lower respiratory tract infections, and unusual susceptibility to infections with herpesvirus family members (herpes simplex virus, human papilloma virus) and molluscum contagiosum.2,3 Cutaneous infections with human papilloma virus have progressed to squamous cell carcinomas in some cases. Immunologic evaluation of DOCK8- deficient patients has revealed T-cell lymphopenia with impaired proliferative responses of both CD41 and CD81 T cells as well as impaired differentiation of TH17 T cells.en_US
dc.description.sponsorshipNIAID NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R21 AI087627, 1R21AI083907, K08 AI076625, P01AI035714, P01 AI035714, R21 AI083907, AI065617, N01 AI400030, AI76625, R01 AI065617, AI087627]; NIAMS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [R01 AR047417, R01 AR047417-08]en_US
dc.identifier.citationMcDonald, D. R., Massaad, M. J., Johnston, A., Keleş, S., Chatila, T., Geha, R. S., Pai, S. Y., (2010). Successful Engraftment of Donor Marrow After Allogeneic Hematopoietic Cell Transplantation in Autosomal-Recessive Hyper-Ige Syndrome Caused by Dedicator of Cytokinesis 8 Deficiency. Journal of Allergy and Clinical Immunology, 126(6), 1304-1305. doi: org/10.1016/j.jaci.2010.07.034.
dc.identifier.doi10.1016/j.jaci.2010.07.034en_US
dc.identifier.endpage1305en_US
dc.identifier.issn0091-6749en_US
dc.identifier.issue6en_US
dc.identifier.pmid20810158en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1304en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jaci.2010.07.034
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25285
dc.identifier.volume126en_US
dc.identifier.wosWOS:000284947800032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKeleş, Sevgi
dc.language.isoenen_US
dc.publisherMOSBY-ELSEVIERen_US
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleSuccessful Engraftment of Donor Marrow After Allogeneic Hematopoietic Cell Transplantation in Autosomal-Recessive Hyper-Ige Syndrome Caused by Dedicator of Cytokinesis 8 Deficiencyen_US
dc.typeLetteren_US

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