Macrophage Migration-İnhibitory Factor is Elevated in Pregnant Women With Gestational Diabetes Mellitus

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dc.contributor.authorYılmaz, Özgür
dc.contributor.authorKüçük, Mert
dc.contributor.authorKebapçılar, Levent
dc.contributor.authorAltındağ, Tamer
dc.contributor.authorYüksel, Arif
dc.contributor.authorYuvanç, Hüseyin Oğuz
dc.contributor.authorDal, Tuba
dc.contributor.authorSavran, Yusuf
dc.date.accessioned2020-03-26T18:30:49Z
dc.date.available2020-03-26T18:30:49Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: In reports, abnormal macrophage migration-inhibitory factor (MIF) production has been associated with several diseases. Furthermore, despite scarce data, increasing evidence suggest that MIF plays a central role in glucose homeostasis and in the development of type 1 and type 2 diabetes. However, serum MIF levels in gestational diabetes mellitus (GDM) have not yet been investigated. To address this question, we performed a prospective study between a group of pregnant women with GDM and healthy pregnant controls. Materials and methods: GDM group consisted of 43 pregnant women, whereas the control group consisted of 40 healthy pregnant women. In the morning after an overnight fast, venous blood was sampled for the measurement of serum concentrations of insulin and MIF. Serum was separated by centrifugation and immediately stored at -80 degrees C until the assay. Results: There was no significant difference between the groups for maternal characteristics. Women with GDM had significantly higher levels of serum insulin (14.37 +/- 9.92 mu U/ml vs. 8.78 +/- 4.35 mu U/ml; p = 0.001) and serum MIF concentrations (11.31 +/- 4.92 ng/ml vs. 5.31 +/- 4.07 ng/ml; p < 0.001) when compared with healthy pregnant control group. Conclusion: Our data demonstrated that serum levels of MIF are significantly elevated in patients with GDM. Our findings indicate that MIF might have a role in GDM; however, there is a need for further investigation.en_US
dc.identifier.citationYılmaz, O., Küçük, M., Kebapçılar, L., Altındağ, T., Yüksel, A., Yuvanç, H. O., Dal, T., Savran, Y., (2012). Macrophage Migration-İnhibitory Factor is Elevated in Pregnant Women With Gestational Diabetes Mellitus. Gynecological Endocrinology, 28(1), 76-79. Doi: 10.3109/09513590.2011.588757
dc.identifier.doi10.3109/09513590.2011.588757en_US
dc.identifier.endpage79en_US
dc.identifier.issn0951-3590en_US
dc.identifier.issn1473-0766en_US
dc.identifier.issue1en_US
dc.identifier.pmid21848392en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://dx.doi.org/10.3109/09513590.2011.588757
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28204
dc.identifier.volume28en_US
dc.identifier.wosWOS:000298003400018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKebapçılar, Levent
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMacrophage migration-inhibitory factoren_US
dc.subjectPregnancyen_US
dc.subjectGestational diabetes mellitusen_US
dc.titleMacrophage Migration-İnhibitory Factor is Elevated in Pregnant Women With Gestational Diabetes Mellitusen_US
dc.typeArticleen_US

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