Serum vitamin D deficiency and its association with systemic disease in exfoliation syndrome

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dc.contributor.authorKocabeyoglu, Sibel
dc.contributor.authorMocan, Mehmet Cem
dc.contributor.authorIrkec, Murat
dc.contributor.authorPinar, Asli
dc.contributor.authorBozkurt, Banu
dc.contributor.authorOrhan, Mehmet
dc.date.accessioned2020-03-26T18:43:19Z
dc.date.available2020-03-26T18:43:19Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To determine the association of serum vitamin D levels with exfoliation syndrome (XFS) and evaluate its impact on co-associated systemic diseases. Methods: Forty patients with XFS and 40 control subjects without XFS were recruited for this study Serum concentrations of 25-hydroxy vitamin D [25(OH) D] were measured by high-performance liquid chromatography Vitamin D deficiency was defined as a serum 25(OH) D concentration of <20 ng/mL. A detailed medical history including hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular stroke, autoimmune disease, and neurologic disorders such as Parkinson disease and Alzheimer disease was recorded. Student t test and chi-square test was used for statistical evaluations. Results: The mean age of patients with XFS and control subjects was 69.6 +/- 8.1 years (range 58-90 years) and 67.1 +/- 6.3 years (range 60-86 years), respectively (p>0.05). Mean 25(OH) D levels did not differ between XFS (19.8 +/- 8.3 ng/mL) and control (19.9 +/- 10.3 ng/mL) groups (p = 0.978). Patients with XFS had higher prevalence of cerebrovascular (p = 0.026) and cardiovascular disease (p = 0.001). There was no association between the systemic disease status and serum vitamin D levels of patients with XFS. Conclusions: Although vitamin D levels were similar between XFS and control subjects, the levels were found to be decreased in both groups. Patients with XFS had a significantly higher prevalence of cerebrovascular and cardiovascular disease as compared to controls independent of their serum 25(OH) D levels. Low vitamin D level does not appear to be linked to XFS in the studied population.en_US
dc.identifier.doi10.5301/ejo.5000246en_US
dc.identifier.endpage531en_US
dc.identifier.issn1120-6721en_US
dc.identifier.issn1724-6016en_US
dc.identifier.issue4en_US
dc.identifier.pmid23564611en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage526en_US
dc.identifier.urihttps://dx.doi.org/10.5301/ejo.5000246
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29809
dc.identifier.volume23en_US
dc.identifier.wosWOS:000324152400010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofEUROPEAN JOURNAL OF OPHTHALMOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectCerebrovascular diseaseen_US
dc.subjectExfoliation syndromeen_US
dc.subjectVitamin Den_US
dc.titleSerum vitamin D deficiency and its association with systemic disease in exfoliation syndromeen_US
dc.typeArticleen_US

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