Association between Serum Total Antioxidant Status and Coronary Microvascular Functions in Patients with SLE

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dc.contributor.authorYilmaz, Sema
dc.contributor.authorCaliskan, Mustafa
dc.contributor.authorKulaksizoglu, Sevsen
dc.contributor.authorCiftci, Ozgur
dc.contributor.authorCaliskan, Zuhal
dc.contributor.authorGullu, Hakan
dc.contributor.authorGuven, Aytekin
dc.date.accessioned2020-03-26T18:24:01Z
dc.date.available2020-03-26T18:24:01Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMortality from cardiovascular disease has been found to be increased in patients with systemic lupus erythematosus (SLE). Coronary flow reserve (CFR) measurement is used both to assess epicardial coronary arteries and to examine the integrity of coronary microvascular circulation. Oxidative stress, enhancing modification of plasma lipids, is also associated with atherosclerotic events in lupus patients. Impairment of CFR and TAS has been shown to be an early manifestation of coronary atherosclerosis. Forty patients with SLE and 33 healthy volunteers were included in this study. Echocardiographic examination included left ventricular myocardial velocity measurements and coronary flow reserve (CFR) measurement. Serum total antioxidant status levels (TAS) also were measured using TAS kit. Lateral myocardial early peak velocity (Em) and lateral Em/Am ratio did not differ between the groups, but lateral myocardial atrial peak velocity (Am) was significantly higher in SLE group than the control group. Baseline coronary diastolic peak flow velocity (DPFV) of left anterior descending was similar in both the groups. However, hyperemic DPFV and CFR (2.50 +/- 0.42 vs. 3.09 +/- 0.45, P < 0.0001) were significantly lower in the SLE group than in the control group. CFR significantly and inversely correlated with CRP and significantly correlated with TAS. Subclinical coronary microvascular dysfunction can occur in SLE patients without traditional cardiovascular risk factors, probably associated with underlying inflammation and impairment of TAS. (Echocardiography 2012;29:1218-1223)en_US
dc.identifier.doi10.1111/j.1540-8175.2012.01797.xen_US
dc.identifier.endpage1223en_US
dc.identifier.issn0742-2822en_US
dc.identifier.issn1540-8175en_US
dc.identifier.issue10en_US
dc.identifier.pmid22931164en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1218en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1540-8175.2012.01797.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27772
dc.identifier.volume29en_US
dc.identifier.wosWOS:000310552800018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSLEen_US
dc.subjectcoronary flow reserveen_US
dc.subjectTASen_US
dc.subjectdiastolic functionen_US
dc.titleAssociation between Serum Total Antioxidant Status and Coronary Microvascular Functions in Patients with SLEen_US
dc.typeArticleen_US

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