Netrin-1 and its receptor Unc5b as markers of periodontal disease

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dc.contributor.authorGunpinar, Sadiye
dc.contributor.authorMeraci, Bilge
dc.contributor.authorDundar, Niyazi
dc.date.accessioned2020-03-26T20:15:23Z
dc.date.available2020-03-26T20:15:23Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractObjectives The aim of this present study was to evaluate the levels of Netrin-1 and Unc5b in periodontal health and disease. Background Netrin-1, acting via its receptor UNC5b, regulates the inflammatory response and takes apart in bone destructive diseases. Methods Samples of gingival crevicular fluid (GCF), whole saliva, and serum were taken from systemically healthy, nonsmoking 20 periodontitis , 20 gingivitis patients, and 20 periodontally healthy subjects at baseline and 4 weeks after nonsurgical periodontal treatment (NSPT). Whole-mouth and site-specific clinical periodontal parameters were recorded. Netrin-1 and Unc5b levels were measured by enzyme-linked immunosorbent assay. Data were analyzed by nonparametric tests. Results Total amount of Netrin-1 in GCF was significantly higher in periodontitis than the others, and the levels were significantly reduced after NSPT. Salivary and serum concentrations of Netrin-1 were significantly different among the study groups (P = .000), and NSPT significantly increased the concentration levels of both salivary and serum Netrin-1 (P < .05). Healthy subjects had significantly lower GCF (P = .001) and conversely, higher salivary and serum levels of Unc5b than the other groups (P = .002). The GCF levels of Unc5b were significantly reduced (P < .01), and conversely, serum concentrations were significantly increased after NSPT (P < .05). GCF Netrin-1 and Unc5b total amounts were positively correlated with clinical parameters (P P < .05) whereas salivary Netrin-1 and Unc5b concentrations were negatively correlated with clinical parameters (P P < .05). Conclusions The results of this study indicate that Netrin-1 and its receptor Unc5b may have essential roles in periodontal inflammation and those can be assumed as useful therapeutic agent to control inflammation and periodontal breakdown.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University, Coordination Unit of Scientific Research Projects [2018.06.05.1269]en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University, Coordination Unit of Scientific Research Projects, Grant/Award Number: 2018.06.05.1269en_US
dc.identifier.citationGunpinar, S., Meraci, B., Dundar, N. (2020). Netrin‐1 And İts Receptor Unc5b As Markers Of Periodontal Disease. Journal Of Periodontal Research, 55,(2), 267-276.
dc.identifier.doi10.1111/jre.12712en_US
dc.identifier.issn0022-3484en_US
dc.identifier.issn1600-0765en_US
dc.identifier.pmid31769036en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jre.12712
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38026
dc.identifier.wosWOS:000498401300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDundar, Niyazi
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF PERIODONTAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcellular immunologyen_US
dc.subjectgingival crevice fluiden_US
dc.subjectinflammationen_US
dc.subjectmacrophagesen_US
dc.subjectnonsurgical periodontal therapyen_US
dc.subjectperiodontal diseaseen_US
dc.titleNetrin-1 and its receptor Unc5b as markers of periodontal diseaseen_US
dc.typeArticleen_US

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