Possible effect of leptin on renal magnesium excretion in adolescent patients with type 1 diabetes

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorKurtoglu, Selim
dc.contributor.authorPirgon, Ozgur
dc.date.accessioned2020-03-26T17:04:02Z
dc.date.available2020-03-26T17:04:02Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground : Hypomagnesaemia and hyperleptinemia are common in patients with diabetes. Moreover, it has been demonstrated that leptin stimulates diuresis and natriuresis. The aim of this study was to evaluate the relationship between serum leptin, serum magnesium (Mg) and urinary Mg/urinary creatinine levels in patients with type 1 diabetes. Methods : Serum leptin and Mg and urinary Mg/urinary creatinine levels were measured in 67 patients with diabetes (33 girls and 34 boys). The age, diabetes duration, anthropometric and metabolic parameters of the subjects were matched between girls and boys. The relation of serum leptin levels to serum and urinary Mg/urinary creatinine levels was assessed. Results : Serum leptin levels of girls with diabetes were higher than those of the boys (14 +/- 5.3 mu g/L vs 5.8 +/- 1.5 mu g/L, P < 0.001, respectively). The differences for serum Mg and for urinary Mg/urinary creatinine levels were not significant between girls and boys with diabetes. Leptin levels were correlated with urinary Mg/urinary creatinine levels in both girls and boys (r = 0.39, P = 0.02 and r = 0.37, P = 0.03, respectively). In a multivariate regression model, leptin emerged as independent correlates for mean urinary Mg/urinary creatinine in both girls and boys with the total variance explained being 14%, and 15%, respectively. Conclusion : The data suggest that serum leptin might be related to increased urinary Mg loss in patients with type I diabetes.en_US
dc.identifier.doi10.1111/j.1442-200X.2006.02227.xen_US
dc.identifier.endpage397en_US
dc.identifier.issn1328-8067en_US
dc.identifier.issn1442-200Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid16911085en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1442-200X.2006.02227.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20615
dc.identifier.volume48en_US
dc.identifier.wosWOS:000239307400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofPEDIATRICS INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectleptinen_US
dc.subjectmagnesiumen_US
dc.subjecttype 1 diabetesen_US
dc.titlePossible effect of leptin on renal magnesium excretion in adolescent patients with type 1 diabetesen_US
dc.typeArticleen_US

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