Prognostic score predicts overall survival following complete urinary tract extirpation

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dc.contributor.authorAkand, Murat
dc.contributor.authorMuilwijk, Tim
dc.contributor.authorVan Der Aa, Frank
dc.contributor.authorGevaert, Thomas
dc.contributor.authorMilenkovic, Uros
dc.contributor.authorMoris, Lisa
dc.contributor.authorBlyweert, Wim
dc.contributor.authorPoppel, Hendrik Van
dc.contributor.authorAlbersen, Maarten
dc.contributor.authorJoniau, Steven
dc.date.accessioned2020-03-26T20:20:26Z
dc.date.available2020-03-26T20:20:26Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To evaluate the oncological outcome and complications of patients treated with complete urinary tract extirpation (CUTE) in our department, and to identify prognostic factors for survival. Methods: Clinico-pathological data of patients treated with one-step or stepwise CUTE between 1999 and 2017 were collected retrospectively. Complications were classified according to the modified Clavien-Dindo classification (CDC) in the early (<= 30 days) and late (>30 days) follow-up. Log-rank test was used to assess independent predictors of overall survival (OS), cancer-specific survival (CSS) and recurrence-free survival (RFS). Results: Twenty-five patients (20 male) underwent CUTE (16 one-step) for BC + unilateral/bilateral UTUC. Minor (CDC 1-2) and major (CDC3-5) complications were observed in 72% and 40% of patients, respectively, in the early postoperative period (<= 30 days). Five (20%) patients died in the perioperative period (CDC 5) with a median OS of 52 days (range: 25-77). Median time to last follow-up or death was 30 months (range: 0-161). Median OS was 50 months (95% Confidence Interval [CI]: 22-118 months), while median CCS and RFS were not reached. The 5-year OS, CSS and RFS were 42.7%, 69.6% and 66.7%, respectively. A score for determining which patients would benefit from CUTE was arbitrarily developed, and showed that the patients with a score of 0-2 points (good prognosis) had a better OS than the patients with a poor prognosis (3-4 points) in the log-rank test. Conclusions: Because of lower OS rates, patients with ESRD or with a CUTE score of 3-4 points are probably not ideal candidates for CUTE.en_US
dc.description.sponsorshipEuropean Urologic Scholarship Program (EUSP)en_US
dc.description.sponsorshipMurat Akand is supported by a clinical scholarship from the European Urologic Scholarship Program (EUSP). Steven Joniau is a senior clinical researcher of the Research Foundation of Flanders (FWO).en_US
dc.identifier.citationAkand, M., Muilwijk, T., Van Der Aa, F., Gevaert, T., Milenkovic, U., Moris, L., Blyweert, W., Poppel, H. V., Albersen, M., Joniau, S. (2020). Prognostic Score Predicts Overall Survival Following Complete Urinary Tract Extirpation. Scandinavian Journal of Urology, 54(1), 70-79.
dc.identifier.doi10.1080/21681805.2020.1716069en_US
dc.identifier.issn2168-1805en_US
dc.identifier.issn2168-1813en_US
dc.identifier.pmid31975650en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1080/21681805.2020.1716069
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38585
dc.identifier.wosWOS:000509085800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkand, Murat.
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofSCANDINAVIAN JOURNAL OF UROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBladder canceren_US
dc.subjectradical cystectomyen_US
dc.subjectupper urinary tract carcinomaen_US
dc.subjectnephroureterectomyen_US
dc.subjectcomplete urinary tract extirpationen_US
dc.titlePrognostic score predicts overall survival following complete urinary tract extirpationen_US
dc.typeArticleen_US

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