Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ROYAL SOC CHEMISTRY
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.
Açıklama
Anahtar Kelimeler
Alchemilla vulgaris agg., enzyme inhibition, Lady's mantle
Kaynak
RSC ADVANCES
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
9
Sayı
64
Künye
Vlaisavljević, S., Jelača, S., Zengin, G., Mimica-Dukić, N., Berežni, S., Miljić, M., Stevanović, Z. D. (2019). Alchemilla vulgaris agg. (Lady's Mantle) from Central Balkan: Antioxidant, Anticancer and Enzyme Inhibition Properties. RSC Advances, 9(64), 37474-37483.
