Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

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dc.authorid0000-0002-1184-9080
dc.contributor.authorVlaisavljevic, Sanja
dc.contributor.authorJelaca, Sanja
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMimica-Dukic, Neda
dc.contributor.authorBerezni, Sanja
dc.contributor.authorMiljic, Milorad
dc.contributor.authorStevanovic, Zora Dajic
dc.date.accessioned2020-03-26T20:12:28Z
dc.date.available2020-03-26T20:12:28Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.en_US
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia [172058, 173013]en_US
dc.description.sponsorshipThis work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia [grant numbers 172058 and 173013].en_US
dc.identifier.citationVlaisavljević, S., Jelača, S., Zengin, G., Mimica-Dukić, N., Berežni, S., Miljić, M., Stevanović, Z. D. (2019). Alchemilla vulgaris agg. (Lady's Mantle) from Central Balkan: Antioxidant, Anticancer and Enzyme Inhibition Properties. RSC Advances, 9(64), 37474-37483.
dc.identifier.doi10.1039/c9ra08231jen_US
dc.identifier.endpage37483en_US
dc.identifier.issn2046-2069en_US
dc.identifier.issue64en_US
dc.identifier.pmid35542286en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage37474en_US
dc.identifier.urihttps://dx.doi.org/10.1039/c9ra08231j
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37463
dc.identifier.volume9en_US
dc.identifier.wosWOS:000501620400040en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherROYAL SOC CHEMISTRYen_US
dc.relation.ispartofRSC ADVANCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlchemilla vulgaris agg.
dc.subjectenzyme inhibition
dc.subjectLady's mantle
dc.titleAlchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition propertiesen_US
dc.typeArticleen_US

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