Effect of sildenafil on platelet function and platelet cGMP of patients with erectile dysfunction

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dc.contributor.authorAkand, M.
dc.contributor.authorGencer, E.
dc.contributor.authorYaman, O.
dc.contributor.authorErisgen, G.
dc.contributor.authorTekin, D.
dc.contributor.authorOzdiler, E.
dc.date.accessioned2020-03-26T19:02:09Z
dc.date.available2020-03-26T19:02:09Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTo investigate the effect of sildenafil on platelet function and cyclic guanosine monophosphate (cGMP) levels in patients with erectile dysfunction, we evaluated the association between erectile function and platelet responses after administration of 100mg sildenafil. Erectile responses were monitored after 8 daily doses of the drug. Adenosine diphosphate (ADP) and collagen-induced platelet aggregation and simultaneous adenosine triphosphate (ATP) release and cGMP levels were determined before and after sildenafil therapy. Basal levels for platelet aggregation, ATP release and cGMP were compared with age-matched controls. There was no difference among basal levels of platelet responses between patients and controls, except for ADP-induced platelet aggregation (P=0.04). It was significantly higher in the patient group. Analysis of the responses to sildenafil revealed that for the patients who showed a positive erectile response, there was a significant increase in platelet cGMP (P=0.028) and a decrease in ADP-induced platelet aggregation (P=0.04). However, for those who showed a negative or poor erectile response, there was no change in platelet cGMP levels and platelet functions. Sildenafil did not affect collagen-induced platelet responses although cGMP levels of the responders increased. It is concluded that sildenafil increases platelet cGMP in the patients with positive erectile response. Therefore, it has been speculated that platelet cGMP may be used as an index for erectile response.en_US
dc.identifier.doi10.1111/and.12387en_US
dc.identifier.endpage1102en_US
dc.identifier.issn0303-4569en_US
dc.identifier.issn1439-0272en_US
dc.identifier.issue10en_US
dc.identifier.pmid25486996en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1098en_US
dc.identifier.urihttps://dx.doi.org/10.1111/and.12387
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32049
dc.identifier.volume47en_US
dc.identifier.wosWOS:000364519800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofANDROLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcGMPen_US
dc.subjecterectile dysfunctionen_US
dc.subjectphosphodiesteraseen_US
dc.subjectplateleten_US
dc.subjectsildenafilen_US
dc.titleEffect of sildenafil on platelet function and platelet cGMP of patients with erectile dysfunctionen_US
dc.typeArticleen_US

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