Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome

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dc.contributor.authorYilmaz, S. A.
dc.contributor.authorKerimoglu, O. S.
dc.contributor.authorPekin, A. T.
dc.contributor.authorIncesu, F.
dc.contributor.authorDogan, N. U.
dc.contributor.authorCelik, C.
dc.contributor.authorUnlu, A.
dc.date.accessioned2020-03-26T18:51:29Z
dc.date.available2020-03-26T18:51:29Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of the present study was to evaluate serum concentrations of metastin in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS). Study design: The study was a clinical study. Eighty-three women with PCOS and 66 body mass index (BMI) matched controls were divided into two groups, based on BMI: overweight and obese (BMI >= 25 kg/m(2)) and normal weight. (BMI < 25 kg/m(2)) Hirsutism scores, hormonal and metabolic profile as well as metastin levels were evaluated in each subject. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 AM, after an overnight fast. Circulating levels of LH, FSH, PRL, TSH, T, fT, DHEAS, 17-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, lipid profile and metastin were measured. Results: Metastin levels were significantly higher in the PCOS group compared to controls (2.02 ng/ml versus 1.16 ng/ml, p < 0.001). Metastin levels correlated significantly positively with luteinizing hormone (LH), total testosterone (T), dehydroepiandrosteronesulphate (DHEA-SO4) levels, modified Ferriman-Gallwey (mFG) scores and free androgen index (FAI); however, correlated negatively with sex hormone binding globulin (SHBG) levels (p < 0.05). When overweight or obese (BMI >= 25 kg/m(2)) and normal weight (BMI < 25 kg/m(2)) women with PCOS were compared to body mass index (BMI) matched controls, higher metastin levels were also found in PCOS groups (1.94 ng/ml versus 1.18 ng/ml, and 2.06 ng/ml versus 1.08 ng/ml, p < 0.05, respectively). Conclusions: These findings suggest that metastin levels were higher in women with PCOS as compared to controls regardless of BMI. Furthermore, metastin levels can be used as a specific marker for androgenic profile and this marker might play a role in the pathogenesis of PCOS. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2014.06.004en_US
dc.identifier.endpage60en_US
dc.identifier.issn0301-2115en_US
dc.identifier.issn1872-7654en_US
dc.identifier.pmid25020276en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage56en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejogrb.2014.06.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30983
dc.identifier.volume180en_US
dc.identifier.wosWOS:000343384700012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMetastinen_US
dc.subjectKisspeptinen_US
dc.subjectPCOSen_US
dc.subjectInsulin resistanceen_US
dc.titleMetastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndromeen_US
dc.typeArticleen_US

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