The Effectiveness of Anti-R. equi Hyperimmune Plasma against R. equi Challenge in Thoroughbred Arabian Foals of Mares Vaccinated with R-equi Vaccine

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dc.contributor.authorErganis, Osman
dc.contributor.authorSayin, Zafer
dc.contributor.authorHadimli, Hasan Huseyin
dc.contributor.authorSakmanoglu, Asli
dc.contributor.authorPinarkara, Yasemin
dc.contributor.authorOzdemir, Ozgur
dc.contributor.authorMaden, Mehmet
dc.date.accessioned2020-03-26T18:58:36Z
dc.date.available2020-03-26T18:58:36Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aimed to determine the effectiveness of a pregnant mare immunization of a Rhodococcus equi (R. equi) vaccine candidate containing a water-based nanoparticle mineral oil adjuvanted (Montanide IMS 3012) inactive bacterin and virulence-associated protein A (VapA), as well as the administration of anti-R. equi hyperimmune (HI) plasma against R. equi challenge in the mares' foals. The efficacy of passive immunizations (colostral passive immunity by mare vaccination and artificial passive immunity by HI plasma administration) was evaluated based on clinical signs, complete blood count, blood gas analysis, serological response (ELISA), interleukin-4 (IL-4) and interferon gamma (IFN-gamma), total cell count of the bronchoalveolar lavage fluids (BALF) samples, reisolation rate of R. equi from BALF samples (CFU/mL), lung samples (CFU/gr), and lesion scores of the organs and tissue according to pathological findings after necropsy in the foals. The vaccination of pregnant mares and HI plasma administration in the foals reduced the severity of R. equi pneumonia and lesion scores of the organs and tissue by 3.54-fold compared to the control foals. This study thus indicates that immunization of pregnant mares with R. equi vaccine candidate and administration of HI plasma in mares' foals effectively protect foals against R. equi challenge.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108 G 030]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (Project no. 108 G 030). This research has been approved (date 15/02/2008 and 2008/010) by the Ethics Committee of the Faculty of Veterinary Medicine at the University of Selcuk in Konya, Turkey.en_US
dc.identifier.doi10.1155/2014/480732en_US
dc.identifier.issn1537-744Xen_US
dc.identifier.pmid24982958en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2014/480732
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31195
dc.identifier.wosWOS:000334216500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofSCIENTIFIC WORLD JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe Effectiveness of Anti-R. equi Hyperimmune Plasma against R. equi Challenge in Thoroughbred Arabian Foals of Mares Vaccinated with R-equi Vaccineen_US
dc.typeArticleen_US

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