Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured In Vitro

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dc.contributor.authorFazliogullari, Z.
dc.contributor.authorKarabulut, A. K.
dc.contributor.authorUysal, I. I.
dc.contributor.authorUnver Dogan, N.
dc.contributor.authorAcar, H.
dc.date.accessioned2020-03-26T18:42:14Z
dc.date.available2020-03-26T18:42:14Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, we aimed to investigate and compare the direct toxic and teratogenic effects of dimenhydrinate, metoclopramide and trimethobenzamide HCl, antiemetic drugs on embryonic growth and development in cultured rat embryos. Embryos were explanted on day 9.5 of gestation and cultured. Whole rat serum was used as a culture medium for the control group while different concentrations of dimenhydrinate (2.5-20 mu g/ml), metoclopramide (10-50 mu g/ml) and trimethobenzamide HCl (25-100 mu g/ml) were added to serum for the experimental groups. Effects of antiemetics on embryonic developmental parameters were compared, and embryos were evaluated for the presence of any malformations. Also, the total DNA was extracted from the cells to determine the fragmentation of nuclear DNA of embryonic cells. Compared with the control embryos, the antiemetics significantly decreased all growth and developmental parameters dose dependently. There was no difference regarding the fragmentation of nuclear DNA of the all used agents and controls. Amongst the agents, trimethobenzamide HCl was found to have more toxic and teratogenic potential, and metoclopramide appears to be the least toxic antiemetic and therefore could be more safely used and might be preferred for the treatment of nausea and vomiting in pregnancy.en_US
dc.description.sponsorshipScientific Research Project Commission of Selcuk UniversitySelcuk University [09102049]en_US
dc.description.sponsorshipThis project was supported by Scientific Research Project Commission of Selcuk University, grant number 09102049.en_US
dc.identifier.doi10.1111/ahe.12007en_US
dc.identifier.endpage246en_US
dc.identifier.issn0340-2096en_US
dc.identifier.issn1439-0264en_US
dc.identifier.issue4en_US
dc.identifier.pmid23002952en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://dx.doi.org/10.1111/ahe.12007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29585
dc.identifier.volume42en_US
dc.identifier.wosWOS:000321459600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofANATOMIA HISTOLOGIA EMBRYOLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleInvestigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured In Vitroen_US
dc.typeArticleen_US

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