Investigation of Cardiomyopathy in Children With Cirrhotic and Noncirrhotic Portal Hypertension

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dc.contributor.authorCeltik, Coskun
dc.contributor.authorDurmaz, Ozlem
dc.contributor.authorOner, Naci
dc.contributor.authorYavuz, Taner
dc.contributor.authorGokce, Selim
dc.contributor.authorAydogan, Aysen
dc.contributor.authorNisli, Kemal
dc.date.accessioned2020-03-26T19:06:11Z
dc.date.available2020-03-26T19:06:11Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Cirrhotic cardiomyopathy (CCMP) is a functional disorder characterized by electrophysiological disturbances, and diastolic and/or systolic dysfunction in patients with liver disease. This disorder is a well-defined entity in adults, but pediatric data are limited. The aim of the study was to determine the incidence, features, and risk factors of CCMP in children with portal hypertension (PHT). Methods: This study included 50 children with cirrhotic PHT (40/50) and noncirrhotic PHT (10/50). Fifty healthy children were also selected for the control group. Electrocardiography and echocardiography were used to evaluate cardiac functions. Corrected QT (QTc) >= 0.45 was accepted as prolonged on electrocardiography. The study group was divided into 3 groups: cirrhotic, noncirrhotic, and control. Then, the CCMP group was created according to the diagnostic criteria. Latent CCMP was diagnosed in the presence of prolonged-QTc along with a minor criterion (tachycardia). Manifest CCMP was diagnosed in the presence of at least 2 major criteria (prolonged-QTc along with abnormal echocardiographic findings). Moreover, in this study, the risk factors for CCMP were investigated. Results: The CCMP group included 10 cases (20%). Nine of these cases had latent CCMP (18%), and the remaining one (2%) had manifest CCMP. All of the cases with CCMP had cirrhosis and ascites. None of the patients with CCMP had severe cardiac symptoms, but they were already using some cardioprotective drugs such as propanolol and spironolactone. As risk factors for CCMP, pediatric end-stage liver disease scores, Child-Pugh scores, and ascites grades were found to be significant for the determination of CCMP. The most important risk factor was ascites severity (P = 0.001, odds ratio 9.4). Conclusions: Approximately 20% of children with PHT have CCMP. A detailed cardiac examination should be carried out periodically in children with cirrhotic PHT, especially in the presence of ascites and high Child-Pugh score.en_US
dc.identifier.doi10.1097/MPG.0000000000000580en_US
dc.identifier.endpage181en_US
dc.identifier.issn0277-2116en_US
dc.identifier.issn1536-4801en_US
dc.identifier.issue2en_US
dc.identifier.pmid25250684en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MPG.0000000000000580
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32257
dc.identifier.volume60en_US
dc.identifier.wosWOS:000349321400009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcardiac dysfunctionen_US
dc.subjectcardiomyopathyen_US
dc.subjectchildrenen_US
dc.subjectchronic liver diseasesen_US
dc.subjectcirrhoticen_US
dc.subjectportal hypertensionen_US
dc.titleInvestigation of Cardiomyopathy in Children With Cirrhotic and Noncirrhotic Portal Hypertensionen_US
dc.typeArticleen_US

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